摘要
目的探讨在类风湿关节炎患者中应用抗环瓜氨酸肽抗体检测的效果,为临床提供指导。方法选择2017年3月～2018年9月来我院治疗的68例类风湿关节炎患者作为观察组,并选择同期接受治疗的50例非类风湿关节炎患者作为对照1组及同期来我院行体检的50例正常人志愿者作为对照2组,对所有观察对象均实施类风湿因子及抗环瓜氨酸肽抗体检测,对比分析所有观察对象类风湿因子及抗环瓜氨酸肽抗体的检测结果。结果 (1)观察组患者治疗后抗环瓜氨酸肽抗体浓度低于患者治疗前,P <0.05;(2)骨侵蚀组患者治疗后的抗环瓜氨酸肽抗体浓度均明显高于非骨侵蚀组患者,且骨侵蚀组Ⅳ期患者治疗后的抗环瓜氨酸肽抗体浓度明显高于Ⅲ期、Ⅱ期、Ⅰ期患者,P <0.05。结论在类风湿关节炎患者中应用抗环瓜氨酸肽抗体检测具有较佳的效果,对诊断患者病情、监测治疗及评估患者治疗效果具有十分积极的作用。
Objective To explore the effect of anti-cyclic citrullinated peptide(anti CCP) antibody detection in patients with rheumatoid arthritis,and to provide guidance for clinical practice. Methods Sixty-eight patients with rheumatoid arthritis treated in our hospital from March 2017 to September 2018 were selected as observation group,and 50 non-rheumatoid arthritis patients treated in the same period were selected as control group 1 and 50 normal volunteers who had physical examination in our hospital during the same period were selected as control group 2.Rheumatoid factor and anti-cyclic citrullinated peptide antibody were detected in all subjects,and the detection results of rheumatoid factor and anti-cyclic citrullinated peptide antibody in all subjects were compared and analyzed. Results(1)The concentration of anti-cyclic citrullinated peptide antibody in the observation group after treatment was lower than that before treatment(P < 0.05);(2)The concentration of anti-cyclic citrullinated peptide antibody in the bone erosion group was significantly higher than that in the nonbone erosion group.After treatment,the concentration of anti-cyclic citrullinated peptide antibody of patients with bone erosion group in the stage IV was significantly higher than that in the stage Ⅲ,Ⅱ and Ⅰ(P < 0.05).Conclusion The application of anti-cyclic citrullinated peptide antibody detection in treatment of rheumatoid arthritis patients has a better effect,patients of diagnosis,monitoring treatment and evaluating curative effect in patients with a very positive role.
作者
秦育滨
陈武生
李妙娜
赖丽思
徐孝伦
QIN Yubin;CHEN Wusheng;LI Miaona;LAI Lisi;XU Xiaolun(Puning Traditional Chinese Medicine Hospital,Puning 515300, China)
出处
《中国医药科学》
2019年第4期21-24,共4页
China Medicine And Pharmacy
基金
广东省揭阳市医学科学技术研究项目(20181079K)
关键词
类风湿关节炎
抗环瓜氨酸肽抗体
类风湿因子
临床检测
Rheumatoid arthritis
Anti-cyclic citrullinated peptide antibody
Rheumatoid factors
Clinical detection
