摘要
目的观察银杏叶提取物联合盐酸多奈哌齐治疗老年性痴呆的临床疗效。方法选择滨州市中心医院2014年5月至2016年3月诊治的116例老年性痴呆患者,随机分为两组,每组58例。对照组给予盐酸多奈哌齐治疗,治疗组在盐酸多奈哌齐基础上加用银杏叶提取物,分析银杏叶提取物对老年性痴呆的效果。结果治疗后9个月,治疗组总有效率(79.31%)高于对照组(60.34%,P<0.05);治疗组阿尔茨海默病评价量表-认知量表(ADAS-cog)、简易精神状态检查量表(MMSE)和日常生活能力量表(ADL)评分均优于对照组(P均<0.05),脑脊液乙酰胆碱(ACh)、血清丙二醛(MDA)和一氧化氮(NO)水平均优于对照组(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论银杏叶提取物可辅助治疗老年性痴呆,其可提高治疗效果,且较安全。
Objective To observe the clinical efficacy of Ginkgo biloba extract combined with donepezil hydrochloride on Alzheimer’s disease.Methods A total of 116 patients with Alzheimer’s disease admitted in Binzhou Central Hospital from May 2014 to March 2016 were divided into two groups randomly,with 58 cases in each group.The patients in control group were treated with donepezil hydrochloride,and the patients in treatment group were treated with Ginkgo biloba extract on the basis of donepezil hydrochloride.The effect of Ginkgo biloba extract on senile dementia was analyzed.Results Nine months after treatment,the total efficiency of treatment group(79.31%)was higher than that of control group(60.34%,P<0.05);the scores of MMSE and ADL were better than those of control group(P all<0.05),and the levels of ACh,MDA and NO in cerebrospinal fluid were better than those of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Ginkgo biloba extract can be used to treat Alzheimer’s disease auxiliary,which can improve the curative effect and is safer.
作者
高立栋
王秀梅
霍胜霞
郭敏
高玲玉
Gao Lidong;Wang Xiumei;Huo Shengxia;Guo Min;Gao Lingyu(Pharmacy Intravenous Admixture Services,Binzhou Central Hospital,Binzhou Tuberculosis Hospital,Binzhou 251700,China;Department of CT,Binzhou Central Hospital,Binzhou Tuberculosis Hospital,Binzhou 251700,China;Department of Neurology,Binzhou Central Hospital,Binzhou Tuberculosis Hospital,Binzhou 251700,China)
出处
《中国实用医刊》
2019年第2期97-100,共4页
Chinese Journal of Practical Medicine
关键词
银杏叶提取物
盐酸多奈哌齐
老年性痴呆
Ginkgo biloba extract
Donepezil hydrochloride
Alzheimer's disease
