摘要
目的观察腰大池引流联合万古霉素鞘内注射治疗高血压脑出血术后颅内感染的临床效果。方法选取医院2017年6月至2018年6月收治的高血压脑出血术后颅内感染患者80例,按随机数字表法分为对照组和研究组,各40例。两组患者均给予积极抢救,并给予万古霉素鞘内注射治疗,研究组患者联合腰大池引流治疗。结果研究组总有效率为90. 00%,显著高于对照组的72. 50%(P <0. 05);治疗后,两组患者的脑脊液中白细胞计数、蛋白质含量均显著减少,葡萄糖含量显著增加,且研究组均优于对照组(P <0. 05);两组患者术后4 d及7 d颅内压均较术前降低,且研究组显著低于对照组(P <0. 05);研究组患者格拉斯哥预后评分显著高于对照组(P <0. 05)。结论腰大池引流联合万古霉素鞘内注射治疗高血压脑出血术后颅内感染疗效确切,可显著降低颅内压,改善感染情况及预后。
Objective To observe the clinical effect of lumbar cistern drainage combined with intrathecal injection of vancomycin in the treatment of intracranial infection after hypertensive intracerebral hemorrhage.Methods Totally 80 patients with intracranial infection after hypertensive intracerebral hemorrhage admitted to our hospital from June 2017 to June 2018 were selected and divided into the control group and the study group according to the random number table method,40 cases in each group.The patients in the two groups were given active rescue and intrathecal injection of vancomycin,on this basis,the patients in the study group were treated with lumbar cistern drainage.Results The total effective rate of the study group was 90.00%,which was significantly higher than 72.50% of the control group(P<0.05).After treatment,the white blood cell count and protein content in cerebrospinal fluid of the two groups were significantly decreased,while the glucose content was significantly increased,and those in the study group were better than those in the control group(P<0.05).4 d and 7 d after the operation,the intracranial pressure of the two groups were decreased compared with those before treatment,and that of the study group was significantly lower than that of the control group(P<0.05).The Glasgow prognosis score of the study group was significantly higher than that of the control group(P<0.05).Conclusion Lumbar cistern drainage combined with intrathecal injection of vancomycin is effective in the treatment of intracranial infection after hypertensive intracerebral hemorrhage,which can significantly reduce intracranial pressure,improve infection and prognosis.
作者
胡晓
李陈
周杨
王振宇
刘坤明
HU Xiao;LI Chen;ZHOU Yang;WANG Zhenyu;LIU Kunming(Tongren People's Hospital,Tongren,Guizhou,China 554300)
出处
《中国药业》
CAS
2019年第8期50-52,共3页
China Pharmaceuticals
基金
2017年度贵州省铜仁市科技计划面上项目[铜科发〔2017〕47-29号]
关键词
腰大池引流
万古霉素
鞘内注射
高血压脑出血
颅内感染
临床疗效
预后
lumbar cistern drainage
vancomycin
intrathecal injection
hypertensive intracerebral hemorrhage
intracranial infection
clinical effect
prognosis
