摘要
铁是机体内最基本元素,参与机体氧运输、细胞呼吸、DNA复制等,铁代谢紊乱与多种疾病相关,包括贫血性疾病(缺铁性贫血、慢性贫血)和铁过载相关疾病(血色素沉着症)等。铁调素是由肝合成的小分子多肽类激素,对机体铁代谢起负向调控作用,对维持机体铁稳态尤为重要。铁调素由Hamp基因编码,其表达由BMP、STAT等多条信号通路调控,白细胞介素(IL)-6、跨膜丝氨酸蛋白酶(TMPRSS)6等信号分子亦在铁调素的调节中发挥重要作用。笔者现就铁调素的分子结构、作用,以及目前针对铁调素、Hamp基因及其相关信号通路的调节药物的研究进展进行综述。
Iron is the most basic element involved in oxygen transport, cell respiration, DNA replication, and other disorders of iron metabolism associated with a variety of diseases, including anemia (iron deficiency anemia, chronic anemia) and iron overload (hemochromatosis). Hepcidin is a small molecule peptide hormone synthesized by the liver, which plays a negative role in regulating iron metabolism and is particularly important for maintaining iron balance. Hepcidin is encoded by Hamp gene, and its expression is regulated by multiple signaling pathways such as BMP and STAT. Signal molecules such as interleukin (IL)-6 and transmembrane serine protease (TMPRSS)6 also play important roles in the regulation of hepcidin. This article reviews the molecular structure and role of hepcidin, as well as the current research progress on regulatory drugs targeting hepcidin, Hamp gene and its related signaling pathways.
作者
陈莹莹
王丽红
郝长来
Chen Yingying;Wang Lihong;Hao Changlai(Department of Hematology,Affiliated Hospital of Chengde Medical College,Chengde 068450,Hebei Province,China)
出处
《国际输血及血液学杂志》
CAS
2019年第1期85-89,共5页
International Journal of Blood Transfusion and Hematology
