摘要
目的探讨矮小及偏矮儿童青少年体重指数(BMI)与血尿酸的相关性。方法横断面调查收集922例矮小及偏矮儿童青少年人群一般临床资料,每例均收集其身高、体重、胰岛素样生长因子Ⅰ(IGF-Ⅰ)、生长激素峰值、尿酸、血脂等指标,并计算其BMI及BMI标准差积分(BMI SDS),运用平滑曲线拟合及多元分段线性回归分析BMI SDS与尿酸的关系。结果单因素分析发现血尿酸与年龄、身高标准差积分、体重标准差积分、BMI SDS、IGF-Ⅰ标准差积分、生长激素峰值、三酰甘油、肌酐成正相关(P<0.05),与高密度脂蛋白胆固醇成负相关(P<0.01),女性较男性血尿酸水平显著降低(P=0.003)。进入青春期后较青春期前的人群血尿酸水平显著升高(P<0.01)。校正潜在混杂因素后平滑曲线拟合显示BMI SDS与尿酸呈U形关系,BMI SDS拐点为-0.7,在BMI SDS<-0.7人群,BMI SDS每增加一个单位,血尿酸降低11.78 μmol/L(P=0.03),在BMI SDS≥-0.7人群中,BMI SDS每增加一个单位,血尿酸升高11.79 μmol/L(P<0.01)。结论BMI似可影响血尿酸水平,消瘦或肥胖都可使血尿酸水平升高。在临床工作中,应重视消瘦及肥胖儿童的血尿酸检测。
Objective To investigate the independent association of the body mass index(BMI) with serum uric acid among shorter children and adolescent. Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures. In each case, their information about height, weight, insulin-like growth factor-Ⅰ(IGF-Ⅰ), growth hormone peak, uric acid, and blood lipids were collected, and their BMI and BMI standard deviations score(SDS) were calculated. Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid. Results Univariate analysis found that serum uric acid was positively correlated with age, height standard deviation score, body weight standard deviation score, BMI SDS, IGF-Ⅰ standard deviation score, growth hormone peak, triglyceride, and creatinine(P<0.05), while negatively correlated with high-density lipoprotein-cholesterol(P<0.01). Female had significantly lower serum uric acid levels than male(P=0.003). The serum uric acid level was significantly increased after puberty(P<0.01). After adjusting for potential confounders, the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid, with a BMI SDS inflection point of -0.7. In the population of BMI SDS<-0.7, for every unit increase of BMI SDS, serum uric acid decreased by 11.78 μmol/L(P=0.030). In the population of BMI SDS≥-0.7, uric acid increased by 11.79 μmol/L(P<0.01) for every unit increase of BMI SDS. Conclusion Serum uric acid levels seem to be affected by BMI, and increased in population with thin or obesity. We should pay attention to the measurement of serum uric acid in both thin and obese children.
作者
赵倩倩
张梅
李萍
孙海玲
班博
邵倩
Zhao Qianqian;Zhang Mei;Li Ping;Sun Hailing;Ban Bo;Shao Qian(Department of Endocrine and Metabolic Diseases, Affiliated Hospital of Jining Medical University, Jining 272000, China;Department of Clinical Medicine, Jining Medical University, Jining 272000, China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2019年第2期128-132,共5页
Chinese Journal of Endocrinology and Metabolism
基金
山东省自然科学基金(ZR2014HP058).
关键词
体重指数
尿酸
儿童青少年
横断面研究
Body mass index
Uric acid
Children and adolescents
Cross-sectional study
