摘要
目的通过分析本院2012年-2016年1 753株大肠埃希菌分布特征及耐药情况,为临床合理使用抗菌药物提供依据。方法采用最低抑菌浓度琼脂稀释法和K-B纸片扩散法对大肠埃希菌进行药物试验,分别对其科室分布、标本来源、药物敏感性及耐药性进行分析。结果共分离出1 753株大肠埃希菌,其中产ESBLs菌839株;非产ESBLs菌914株,主要分布在神经外科、ICU科、神经内科和呼吸内科。主要标本来源为尿液、血液、痰液。大肠埃希菌产ESBLs菌株对青霉素类、酶抑制剂类、头孢菌素类、喹诺酮类、氨基糖苷类的耐药率明显高于非产ESBLs菌株,对碳青霉烯类抗生素仍高度敏感。结论大肠埃希菌中广泛耐药大肠埃希菌菌株的检出率呈上升趋势,给临床抗感染治疗带来挑战,应采取措施积极防控。
Objective By analyzing the distribution characteristics and drug resistance of 1753 cases of Escherichia coli in our hospital from 2012 to 2016,to provide basis for the rational use of antibacterial drugs in clinical practice.Methods The drug test of Escherichia coli with positive bacterial culture was carried out by using the lowest bacteriostatic concentration AGAR dilution method and K-B paper diffusion method.The department distribution,sample source,drug sensitivity and drug resistance were analyzed.Results A total of 1753 cases of Escherichia coli were isolated,including 839 strains of ESBLs and 914 strainsnon-ESBLs,which were mainly distributed in neurosurgery,ICU,neurology and respiratory medicine.The main samples were from urine,blood and sputum.Drug sensitivity of Escherichia coli producing ESBLs resistant to penicillin,enzyme inhibitors,cephalosporin,quinolones and glucoside was significantly higher than that of non-ESBL strains.It was also high sensitive to carbapenems.Conclusion The detection rate of extensively resistant Escherichia coli strain in Escherichia coli was on the rise,which brought challenge to the clinical anti-infection treatment.Therefore,relevant measures should be taken to active prevention and control.
作者
孙景熙
王福斌
陈剑明
孙永宁
SUN Jing-xi;WANG Fu-bin;CHEN Jian-ming;SUN Yong-ning(Intensive Care Unit,the Sixth Hospital of Ningbo,Ningbo,Zhejiang 315040,China)
出处
《中国卫生检验杂志》
CAS
2019年第6期669-672,共4页
Chinese Journal of Health Laboratory Technology
关键词
大肠埃希菌
细菌分布
耐药性
广泛耐药大肠埃希菌
合理用药
Escherichia coli
Bacterial distribution
Drug resistance
Extensively resistant Escherichia coli
Rational drug use
