摘要
目的研究一种聚六亚甲基双胍盐酸盐抗菌液的杀菌效果及安全性。方法通过杀菌试验、现场消毒试验和动物毒性试验,对该抗菌液进行实验室检测和评价。结果用该抗菌液对悬液内的白色念珠菌、金黄色葡萄球菌和大肠杆菌分别作用3 min、6 min和9 min,其对白色念珠菌杀灭对数值>4.0,对金黄色葡萄球菌和大肠杆菌杀灭对数值均>5.0,该抗菌液对皮肤自然菌的平均杀灭对数值为2.16,对豚鼠完整皮肤无刺激作用,对家兔眼睛和阴道黏膜无刺激性。结论该聚六亚甲基双胍盐酸盐抗菌液消毒性能优良,对皮肤及黏膜安全性较高。
Objective To research the germicidal efficacy and safety of a polyhexamethylene biguanidine hydrochloride antiseptic solution. Methods Germicidal test, field disinfection test and animal toxicity test were carried out to observe the germicidal efficacy and safety of this antiseptic solution. Results The average killing log value of this antiseptic solution for Candida albicans after 3 min, 6 min and 9 min exposure was more than 4.0. Those of Staphylococcus aureus and Escherichia coli were more than 5.0. That of the natural bacteria on skin was 2.16, and the antiseptic solution had no irritation to the complete skin of guinea pigs and the eyes of rabbits. Conclusion The polyhexamethylene biguanidine hydrochloride antiseptic solution had excellent disinfection performance and high safety for skin and mucosa.
作者
戴陈伟
蔡标
刁慧敏
江杨帆
王超
朱倩云
DAI Chen-wei;CAI Biao;DI AO Hui-min;JIANG Y ang-fan;WANG Chao;ZHU Qian-yun(Anhui Academy of Medical Sciences, Hefei, Anhui 230061 , China)
出处
《中国卫生检验杂志》
CAS
2019年第5期517-519,共3页
Chinese Journal of Health Laboratory Technology
基金
安徽省"十三五"医疗卫生重点专科建设项目"病原微生物实验室"
关键词
聚六亚甲基双胍
杀菌效果
现场消毒试验
安全性
Polyhexamethylene biguanidine hydrochloride
Germicidal efficacy
Field disinfection test
Safety
