摘要
目的:探讨降钙素原(PCT)与几种炎症和凝血指标联合检测在慢性阻塞性肺疾病(COPD)中的临床意义及其对慢性阻塞性肺疾病急性加重期(AECOPD)的诊断价值.方法:随机选择在本院诊治的COPD患者114例,分为慢性阻塞性肺疾病稳定期(SCOPD)组(68例)和AECOPD组(46例),检测其血液PCT、血清淀粉样蛋白A(SAA)、超敏C反应蛋白(h-CRP)、白细胞(WBC)、纤维蛋白原(FIB)、D-二聚体(D-D)等指标,然后将检测结果在两组之间进行比较并作出AECOPD的诊断试验.结果:AECOPD组6项指标均值均明显高于参考区间;除FIB外,其余5项指标均值均明显高于SCOPD组(P<0.05和<0.01).PCT阳性率在SCOPD组仅1.5%、在AECOPD组达95.7%,SAA和h-CRP阳性率在SCOPD组达80%以上,AECOPD组6项指标的阳性率均明显高于SCOPD组(P<0.05和<0.01).PCT对于AECOPD的敏感性和特异性均很高,分别为95.7%和98.5%.结论:PCT与几项炎症和凝血指标联合检测能揭示COPD的炎症严重程度和是否有血栓形成,PCT对AECOPD有很好的诊断价值.
Objective: To probe into the clinical significance of procalcitonin ( PCT ) combined detection with the several inflammation and blood coagulation markers in the chronic obstructive pulmonary disease (COPD) and the diagnostic value of these markers for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: The 114 COPD patients were randomly selected and were divided into the stable chronic obstructive pulmonary disease (SCOPD) group (68cases) and the COPD group (46cases). These blood markers of patients were determined such as the PCT, serum amyloid A (SAA), high sensitivity C-reactive protein (h-CRP), white blood cell (WBC), fibrinogen (FIB) and D-dimer.The detennined results were compared between two groups and the diagnostic tests were made in AECOPD. The diagnostic parameters of these makers were compared in the bacterial pneumonia. Results: The average value of six markers for the AECOPD group was obviously raised in contrast to reference scope. The average value of five markers except FIB for the AECOPD group was obviously raised in contrast to the SCOPD group (P<0.05 and P<0.01). The positive rate of PCT was only 1.5% for the SCOPD group and reached 95.7% for the AECOPD. The positive rate of SAA and h-CRP reached 95.7% in the SCOPD group. The positive rates of six markers for the AECOPD group were obviously risen in contrast to the SCOPD group (P<0.05 and P<0.01). The sensitivity and specificity of PCT all were high for the AECOPD and were respectively 95.7% and 98.5%. Conclusion: The combined detection of PCT with the several inflammation and coagulation markers can reveal the serious degree of inflammation and whether or not the thrombosis for the COPD. PCT has all-right the diagnostic value for the AECOPD.
作者
华关民
唐荣德
苏群志
张冠新
陈森雄
HUA Guan-niin;TANG Rong-de;SU Qun-zhi(Guangzhou Chinese Medicine University attached xinhui Chinese medicine hospital clinical laboratory,Jiangmen,Guangdong,529100)
出处
《医学检验与临床》
2019年第1期9-11,5,共4页
Medical Laboratory Science and Clinics
关键词
降钙素原
炎症指标
凝血指标
诊断试验
慢性阻塞性肺疾病
Procalcitonin
Inflammation marker
Blood coagulation marker
Diagnostic test
Chronic obstructive pulmonary disease
