摘要
目的:初步对中药戒烟贴联合"5A"方案干预烟草依赖人群(痰瘀互结证)进行疗效评价。方法:将60例烟草依赖人群随机分为观察组和对照组,观察组每日给予中药戒烟贴进行穴位贴敷,对照组每日给予尼古丁贴片贴敷,两组均配合"5A"戒烟干预方案。治疗6周后,评价两组治疗前后中医证候评分;比较两组治疗前、治疗2周、4周、6周FTND评分、MNWS评分、呼气CO值、每日吸烟量。随访2周,比较两组第8周点吸烟戒断率及复吸率。结果:治疗后观察组在有吸烟欲望减少烟量则胸闷、痰多、烦躁易怒、失眠多梦这4个中医症状评分均明显低于对照组(P<0.05);两组治疗FTND评分、MNWS评分及呼气CO值均较治疗前明显下降,具有统计学意义(P<0.01),且治疗后两组之间无统计学差异(P>0.05);两组治疗后各访视点日吸烟量均呈递减趋势;8周时两组戒断率无明显差距,但复吸率对照组明显高于观察组。结论:中药穴位贴敷联合"5A"干预措施,能取得同尼古丁替代品的相同疗效,但在缓解相关中医临床症状更具优势,使患者更为舒适地戒烟。而且药效持续时间更长,复吸率明显低于对照组。
Objective:To preliminary evaluate the curative effect of TCM quit smoking paste combined with"5 A"program on tobacco dependent population with syndrome of phlegm and blood stasis. Methods:60 patients were randomly divided into observation group(30 cases)and control group(30 cases). The observation group was given TCM quit smoking paste daily,while the control group was given nicotine sticker daily. Both groups cooperated with the"5 A"program. After 6 weeks’ treatment,TCM syndrome scores of the two groups were evaluated before and after treatment. The FTND score,MNWS score,expiratory CO and daily smoking volume of the two groups were compared in before treatment,2 weeks,4 weeks and 6 weeks after treatment. After 2 weeks of follow-up,tobacco abstinence rates and relapse rate were compared between the 2 groups at eighth weeks. Results:After treatment,the scores of four TCM symptoms when smoking was reduced in the observation group were significantly lower than those in the control group(P<0.05),such as smoking desire,chest tightness,phlegm,irritability,insomnia and dreaming(P<0.05).FTND score,MNWS score and expiratory CO of the two groups after treatment were significantly lower than those before treatment,with statistical significance(P<0.01),and there was no statistical difference between the two groups after treatment(P>0.05). The daily smoking volume of the two groups showed a decreasing trend at each visit day after treatment. There was no significant difference in tobacco abstinence rates between the two groups at 8 weeks,but relapse rate in the control group was significantly higher than that in the observation group. Conclusion:The intervention of TCM quit smoking paste combined with"5 A"program can achieve the same effect as nicotine substitutes,but it has more advantages in alleviating the clinical symptoms,so that patients can quit smoking more comfortably. Moreover,the duration of drug efficacy was longer and relapse rate was significantly lower than that of the control group.
作者
郑忻
曲妮妮
马丽佳
赵克明
秦一冰
李思佳
徐欣
ZHENG Xin;QU Nini;MA Lijia;ZHAO Kerning;QIN Yibing;LI Sijia;XL Xin(Affiliated Hospital of Liaoning University of Traditioncil Chinese Medicine,Shenyang 110032 ,Liaoning,China;Liaoning University of Traditional Chinese Medicine ,Shenyang 110847 ,Litioning,China)
出处
《辽宁中医药大学学报》
CAS
2019年第3期113-116,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家中医药管理局"十一五"中医药重点学科中西医结合临床学科建设项目(国中医药发[2009]30号)
关键词
烟草依赖
穴位贴敷
中药
tobacco dependence
acupoint application
traditional Chinese medicine
