摘要
目的观察调强放疗同步替吉奥化疗治疗局部晚期或复发性直肠癌的耐受性、近期疗效及远期疗效。方法将71例不能手术的局部晚期或复发性直肠癌患者随机分为实验组(调强放疗同步替吉奥化疗)和对照组(调强放疗同步卡培他滨化疗)。调强放疗总剂量:肿瘤区:66～70 Gy/33～35/F,盆腔:50 Gy/25/F。实验组同步给予2周期的替吉奥化疗,放疗结束后再给予2周期替吉奥辅助化疗。对照组采用卡培他滨化疗。比较两组的治疗效果。结果两组的总有效率、疾病控制率, 1年、 2年、 3年累积生存率及中位生存期比较差异均无统计学意义(P>0.05)。实验组的手足综合征发生率为47.2%,显著低于对照组的77.1%(P <0.01)。结论调强放疗同步替吉奥化疗治疗局部晚期或复发性直肠癌的效果与卡培他滨相似,但患者依从性高,耐受性更好,手足综合征发生率较低,是一种有效的临床治疗方法,值得临床应用。
Objective To observe the tolerance, short-term effect and long-term effect of intensity modulated radiotherapy combined with S-1 concurrent chemoradiotherapy in the treatment of locally advanced or recurrent rectal cancer. Methods 71 cases of patients with unresectable locally advanced or recurrent rectal cancer were randomly divided into experimental group(intensity modulated radiotherapy combined with S-1 concurrent chemoradiotherapy) and control group(intensity modulated radiotherapy combined with capecitabine concurrent chemoradiotherapy). Total dose of intensity modulated radiotherapy: 66 ~ 70 Gy/33 ~ 35/F(tumor area), 50 Gy/25/F(pelvic cavity). The experimental group was synchronously given 2 cycles of S-1 chemotherapy, and then was given 2 cycles of S-1 adjuvant chemotherapy after radiotherapy. The control group was given capecitabine chemotherapy. The effects of the two groups were compared.Results No statistical difference was found in the total effective rate, the disease control rate, and the 1-year, 2-year and 3-year cumulative survival rate and the median survival time between the two groups(P>0.05). The incidence of hand-foot syndrome of the experimental group was 47.2%, significantly lower than 77.1% of the control group(P<0.01). Conclusions Intensity modulated radiotherapy combined with S-1 concurrent chemoradiotherapy in the treatment of locally advanced or recurrent rectal cancer has similar effect with capecitabine,with high compliance, better tolerance and lower incidence rate of hand-foot syndrome, which is an effective clinical treatment method and is worthy of clinical application.
作者
王新宁
赖德星
杜月群
杨帆
WANG Xinning;LAI Dexing;DU Yuequn;YANG Fan(Department of Oncology,the First Affiliaied Hospital of Guangdong,Pharmaceutical University,Guangzhou 510080,China)
出处
《临床医学工程》
2019年第3期320-322,共3页
Clinical Medicine & Engineering
关键词
局部晚期或复发性直肠癌
调强放疗
替吉奥化疗
不良反应
Locally advanced or recurrent rectal cancer
Intensity modulated radiotherapy
S-1 chemotherapy
Adverse reaction
