摘要
目的探讨前列地尔治疗冠心病患者的临床效果及其对患者心肌微循环、血液流变学的影响。方法选择温岭市第一人民医院2015年1月至2017年10月收治的冠心病患者100例,采用随机数字表法分为两组,每组50例。对照组采用常规治疗,观察组在常规治疗基础上加用前列地尔治疗,比较两组患者的临床疗效、心肌微循环指标、血液流变学指标。结果观察组总有效率为96%(48/50),对照组为82%(41/50),两组差异有统计学意义(χ^2=5.005,P<0.05)。治疗后,观察组心肌肌钙蛋白I、心肌肌钙蛋白T分别为(0.023±0.014)μg/L、(0.012±0.006)μg/L,对照组分别为(0.037±0.015)μg/L、(0.019±0.008)μg/L,两组差异均有统计学意义(t=4.825、4.950,均P<0.05);观察组红细胞比容、红细胞电泳时间、红细胞沉降率、血浆黏度分别为(25.69±3.87)%、(293.42±12.73)s、(15.21±4.59)mm/h、(1.29±0.37)mp/s,对照组分别为(32.54±4.52)%、(326.17±18.65)s、(21.85±5.93)mm/h、(1.76±0.43)mp/s,两组差异均有统计学意义(t=8.140、10.256、6.261、5.859,均P<0.05)。结论采用前列地尔治疗冠心病可提高临床疗效,有效改善患者的心肌微循环及血液流变学指标。
Objective To investigate the clinical effect of alprostadil in the treatment of coronary heart disease and its effect on myocardial microcirculation and hemorheology. Methods From January 2015 to October 2017, 100 patients with coronary heart disease admitted to the First People's Hospital of Wenling were randomly divided into two groups according to the digital table, with 50 cases in each group.The control group was treated with routine therapy.The observation group was treated with alprostadil on the basis of routine treatment.The clinical efficacy, myocardial microcirculation index and hemorheology index were compared between the two groups. Results The total effective rate of the observation group was 96%(48/50), which was higher than 82%(41/50) of the control group, and the difference between the two groups was statistically significant(χ^2=5.005, P<0.05). After treatment, the cardiac troponin I and myocardial troponin T in the observation group were (0.023±0.014)μg/L,(0.012±0.006)μg/L, respectively, which in the control group were (0.037±0.015)μg/L,(0.019±0.008)μg/L, respectively, the differences between the two groups were statistically significant(t=4.825, 4.950, all P<0.05). The erythrocyte hematocrit, plasma viscosity, erythrocyte sedimentation rate, erythrocyte electrophoresis time in the observation group were (25.69±3.87)%,(293.42±12.73)s,(15.21±4.59)mm/h,(1.29±0.37)mp/s, respectively, which in the control group were (32.54±4.52)%,(326.17±18.65)s,(21.85±5.93)mm/h,(1.76±0.43)mp/s, respectively, the differences between the two groups were statistically significant (t=8.140, 10.256, 6.261, 10.256, all P<0.05). Conclusion Alprostadil in the treatment of coronary heart disease can improve the clinical efficacy and improve the patients' myocardial microcirculation and hemorheological indicators.
作者
董梦倩
林晓阳
吴福斌
江巧红
Dong Mengqian;Lin Xiaoyang;Wu Fubin;Jiang Qiaohong(Department of Integrated Chinese and Western Medicine,the First People 5 Hospital of Wenling,We riling,Zhejiang 317500,China)
出处
《中国基层医药》
CAS
2019年第5期532-535,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省温岭市科技计划项目(2013c31099).
关键词
冠状动脉疾病
前列地尔
微循环
血液流变学
Coronary artery disease
Alprostadil
Microcirculation
Hemorheology
