摘要
阿尔茨海默病(Alzheimer′s disease,AD)是一种主要表现为伴随进行性记忆丧失的认知功能障碍和行为障碍的神经退行性疾病,目前还未发现能够治愈AD的有效方法或药物。近年来研究发现p75神经营养因子受体(p75NTR)在AD的发病过程中起重要作用,而p75NTR的胞外域(p75ECD)具有神经保护作用,能减缓AD的病理进程,成为AD防治中一个潜在的具有前景的研究靶点。本文综述了近年来关于p75ECD在AD防治中的相关研究,以便研究者掌握目前研究进展,为开发新的治疗阿尔茨海默病的方法和药物提供参考和依据。
Alzheimer′s disease(AD)is a neurodegenerative disease characterized by cognitive impairments with progressive loss of memory and behavioral disorder.Up to now,there is no effective therapy or drug to cure AD.Recent studies have shown p75 neurotrophin receptor(p75NTR)plays a critical role in the pathogenesis of AD,while the extracellular domain of p75 neurotrophin receptor(p75ECD)has neuroprotective effect and can attenuate the development and progression of AD.Therefore,p75ECD is a research-hotspot for prevention and treatment of AD.Here,recent studies are reviewed to learn about the advances of p75ECD in the prevention and therapy of AD and provide references for getting novel methods and drugs to treat AD.
作者
刘华乙
张韬韬
谷涓华
曾跃勤
Liu Huayi;Zhang Taotao;Gu Juanhua;Zeng Yueqin(Yunnan Key Laboratory of Stem Cells and Regenerative Medicine,Institute of Molecular and Clinical Medicine of Kunming Medical University,Kunming 650500,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2019年第3期226-231,共6页
Chinese Journal of Neurology
基金
云南省科技厅-昆明医科大学应用基础研究联合专项项目(2017FE468(-183))
云南省科技计划重大科技专项(生物医药)项目(2018ZF002).
关键词
p75NTR胞外域
阿尔茨海默病
研究进展
Extracellular domain of p75 neurotrophin receptor
Alzheimer disease
Progress
