摘要
目的探讨帕金森病合并功能性便秘的中医证候特征。方法 296例帕金森病患者依据功能性便秘诊断标准分为便秘组123例和非便秘组173例。应用帕金森病证候量表(PD-PES-13)对两组受试者进行中医证候评分。比较两组中医证候积分和各证候分布频率,并用Logistic回归法分析中医证候对帕金森病合并功能性便秘发病的危险度。结果便秘组肾虚、气虚、阴虚、髓减、阳亢、内热、肝风的积分显著高于非便秘组(P <0. 05),肾虚、阴虚、阳亢、内热、肝风的分布频率显著高于非便秘组(P <0. 05)。中医证候对帕金森病便秘危险度的分析显示,帕金森病合并功能性便秘的发生与阴虚(r=1. 006,P=0. 001)、阳亢(r=0. 748,P=0. 003)、内热(r=0. 747,P=0. 003)、肝风(r=0. 733,P=0. 008)、肾虚(r=0. 516,P=0. 031)具有正相关性。结论帕金森病合并功能性便秘患者的中医证候以阴虚、阳亢、内热、肾虚、肝风、气虚、髓减为主。
Objective To investigate the characteristics of traditional Chinese medicine(TCM)syndromes of Parkinson’s disease(PD)complicated with functional constipation.Methods A total of 296 patients with PD were divided into constipation group(123 cases)and non-constipation group(173 cases)according to the diagnostic criteria of functional constipation.The TCM syndrome scores of both groups were measured using PD-Pattern Element Scale-13(PD-PES-13).The TCM syndrome scores and syndrome distribution frequency of two groups were compared,and the risk of TCM syndromes on PD complicated with functional constipation was calculated by Logistic regression.Results The scores of kidney deficiency,qi deficiency,yin deficiency,marrow reduction,yang hyperactivity,internal heat and liver wind in the constipation group were significantly higher than those in the non-constipation group(P<0.05).The distribution frequency of kidney deficiency,yin deficiency,yang hyperactivity,internal heat and liver wind in the constipation group was significant higher than that the non-constipation group(P<0.05).Analysis of the risk of PD constipation by TCM syndrome showed that PD constipation occurrence had positive correlation yin deficiency(r=1.006,P=0.001),yang hyperactivity(r=0.748,P=0.003),internal heat(r=0.747,P=0.003),liver wind(r=0.733,P=0.008),and kidney deficiency(r=0.516,P=0.031).Conclusion The TCM syndromes of patients with PD complicated with function constipation are mainly yin deficiency,yang hyperactivity,internal heat,kidney deficiency,liver wind,qi deficiency and marrow reduction.
作者
张天清
时晶
李婷
秦斌
樊东升
李小刚
刘娜
李雨濛
周沪方
田浩林
纪显玥
贾冬冬
田金洲
ZHANG Tianqing;SHI Jing;LI Ting;QIN Bin;FAN Dongsheng;LI Xiaogang;LIU Na;LI Yumeng;ZHOU Hufang;TIAN Haolin;JI Xianyue;JIA Dongdong;TIAN Jinzhou(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700;Beijing Hospital;Peking University ThirdHospital)
出处
《中医杂志》
CSCD
北大核心
2019年第6期518-521,共4页
Journal of Traditional Chinese Medicine
基金
首都卫生发展科研专项(首发2014-1-4191)
首都临床特色应用研究(Z141107002515019)
关键词
帕金森病
功能性便秘
证候特征
危险度
Parkinson's disease
functional constipation
syndrome characteristics
risk factor
