摘要
目的:系统评价补阳还五汤辅助治疗周围神经损伤的临床疗效和安全性。方法:计算机检索中国知网(CNKI)、万方、维普(VIP)、中国生物医学文献(CBM)等数据库中关于补阳还五汤治疗周围神经损伤的临床随机对照试验(RCT)的文献,对符合纳入标准的文献采用Cochrane评价手册5.1推荐的RCT质量评价工具行方法学质量评价,提取患者一般资料及临床疗效优良率、桡神经功能评分和不良反应发生率,采用RevMan5.3软件对上述数据行Meta分析。结果:共纳入8篇RCT,共849例患者。经Meta分析显示:与对照组相比,试验组临床疗效优良率显著提高[RR=1.28,95%CI(1.19,1.37),Z=6.95,P<0.001];桡神经功能评分显著改善[SMD=1.28,95%CI(1.09,1.47),Z=13.13,P<0.001];不良反应发生率差异无统计学意义[RR=0.90,95%CI(0.41,1.98),Z=0.26,P=0.79]。结论:补阳还五汤辅助治疗周围神经损伤较单纯西医治疗可显著提高临床疗效和桡神经功能评分,且不增加不良反应的发生率。
Object ive: To systematically evaluate the clinical efficacy and safety of Buyang Huanwu decoction (BHD) in the adjuvant treatment of peripheral nerve injury. Methods: The compuler-based search of CNKI, Wanfang, VIP, and CBM database on the treatment of peripheral nerve injury with BHD, the choice of literature was based on randomized controlled trials (RCT). The tool of RCT quality assessment recommended by the Cochrane Evaluation Manual 5.1 which was used for the methodological quality evaluation with the literature that meets the inclusion criteria. The general data of the patient and the clinical efficacy rate, the sacral nerve function score and the incidence of adverse reactions are extracted. The RevMan5.3 was used for the Meta-analysis. Results: A total of 8 RCTs were included, for a total of 849 patients. Meta-analysis results showed that the clinical efficacy of the experimental group was significantly improved compared with the control group [RR=1.28,95% CI (1.19, 1.37), Z=6.95, P<0.001], and the sacral nerve function score was significantly improved[SMD]=1.28, 95% CI (1.09, 1.47), Z = 13.13, P<0.001];there was no significant d iff ere nee in the incidence of adverse reactions[RR=0.90, 95% CI (0.41, 1.98), Z=0.26, P= 0.79]. Conclusion: BHD for the adjuvant treatment of peripheral nerve injury can significantly improve the clinical efficacy and sacral nerve function score compared with western medicine treatment alone, and does not increase the incidence of adverse reactions.
作者
刘洪文
陈锦成
朱国涛
徐杰
LIU Hongwen;CHEN Jingchen;ZHU Guotao;XU Jie(Fujian University of Tradition Chinese Medicine Fujian Fuzhou 350001, China;Fujian Provincial Hospital Fujian Fuzhou 350001, China)
出处
《中医药临床杂志》
2019年第3期486-490,共5页
Clinical Journal of Traditional Chinese Medicine
基金
福建省卫生厅中青年骨干人才项目(2013-ZQN-ZD-1)
关键词
补阳还五汤
周围神经损伤
META分析
Buyang Huanwu decoction: Peripheral nerve injury
Meta-analysis
