摘要
目的 探讨中药黄独零余子致肝损伤临床特点、诊断、治疗及预后.方法 收集2014年11月-2017年6月经本院诊断为黄独零余子相关性肝损伤45例患者的临床资料,采用国际医学组织理事会推荐的药物性肝损伤分型标准从临床表现、实验室检查结果、治疗与转归方面进行分析.结果 45例患者中男性26例、女性19例;服药时间1周至2年不等;所有患者发病时生化学指标异常,其中45例ALT(608.11±411.30)U/L、AST(505.38±342.15)U/L均升高,42例TBil(170.10±136.86)μmol/L增高,22例碱性磷酸酶(182.38±55.15)U/L增高,43例谷氨酰转肽酶(223.12±131.85)U/L增高;临床分型中,肝细胞损伤型38例、胆汁淤积型0例、混合型5例,肝脏生化学检查异常2例;治疗与转归中,死亡1例,其余44例患者均康复.结论 黄独零余子引起的肝损伤以肝细胞损伤型为主,发病机制尚不明确,临床应合理、适量使用,用药期间定期进行肝脏生化学检测.
Objective To explore the characteristics, diagnosis, treatment and prognosis of liver injury caused by the deficiency of dioscorea bulbifera L.. Methods The general data, clinical manifestation and laboratory examination of 45 cases of liver injury diagnosed as Yoshimoto associated liver injury from November 2014 to June 2017 were classified and reviewed with the standards of drug liver injury classification recommended by the Council of international medical organizations. Results The number of male patients was 26, and female 19. The medication time ranged from 1 week to 2 years and the main biochemical performance was abnormal, namely ALT, AST, TBil, DBil, ALP and GGT. Of the 45 cases, the average values of ALT, AST were 608.11 ± 411.30 U/L and 505.38 ± 342.15 U/L. The TBil of 42 case rised with the mean value 170.10 ± 136.86 μmol/L, and the ALP of 22 cases with 182.38 ± 55.15 U/L. The GGT of 43 cases rised with the mean 223.12 ± 131.85 U/L. Clinical classification included 38 cases were liver cell injury, none was cholestasis, 5 mixed types and 2 cases of liver biochemical examination abnormality. One patient died while the other patients recovered. Conclusions Although the pathogenesis of the liver cell induced injury type with dioscorea bulbifera L. remains unclear, the reasonable and appropriate use of medication and regular liver biochemical tests is necessary.
作者
谢群
周宝勤
王美娟
Xie Qun;Zhou Baoqin;Wang Meijuan(Infectious Disease of Haian Hospital Affiliated to Nantong University, Haian 226600, China)
出处
《国际中医中药杂志》
2019年第3期248-251,共4页
International Journal of Traditional Chinese Medicine
基金
南通市科技计划指导性项目(GJZ16123).
关键词
化学及药物性肝损伤
黄独零余子
中药不良反应
Chemical and drug induced liver injury
Dioscorea bulbifera L.
Traditional Chinese drug adverse reaction
