摘要
阿尔茨海默病(Alzheimer’s Disease, AD)是一种慢性神经系统退行性疾病,AD的主要病理表现为脑组织中的老年斑和神经纤维缠结,老年斑的主要成分是异常积聚的β-淀粉样蛋白,过度磷酸化的tau蛋白是神经纤维缠结的主要成分。研究发现AD患者脑内微小RNA表达异常,且证据表明微小RNA参与β-淀粉样蛋白过量生成和tau蛋白过度磷酸化等Alzheimer样病理机制,在AD的发病中起着重要作用。本文就微小RNA在tau蛋白过度磷酸化中的作用及机制进行概述。
Alzheimer’s disease (AD) is a chronic neurodegenerative disease. The main pathological manifestations of AD are senile plaques and neurofibrillary tangles in brain tissue. The main component of senile plaques is abnormal accumulation of β-amyloid( Aβ) and the main component of neurofibrillary tangles is hyperphosphorylated tau protein. It has been found that the abnormal expression of microRNA in the brain of AD patients is involved in the Alzheimer-like pathological mechanisms including overproduction of Aβ and hyperphosphorylation of tau protein, which plays an important role in the pathogenesis of AD. This article summarizes the mechanism and role of microRNAs in the hyperphosphorylation of tau protein.
作者
刘佳惠
徐丹
宋波
廖华强
应明
徐慧文
郭超钦
黎玲玲
罗友根
Liu Jiahui;Xu Dan;Song Bo;Liao Huaqiang;Ying Ming;Xu Huiwen;Guo Chaoqin;Li Lingling;Luo Yougen(The Research Center of Neurodegenerative Diseases and Aging,Medical College of Jinggangshan University,Ji’An,343009;JizhouDistrict Center for Disease Control and Prevention,Ji’An,343000)
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2019年第1期76-80,共5页
Chinese Journal of Histochemistry and Cytochemistry
基金
国家自然科学基金(31660271)
江西省自然科学基金(20181BAB204009)
江西省教育厅科技课题(GJJ160731)
井冈山大学博士启动基金(kt-1364-1)
大学生创新创业计划(201810419008
201710419023
2017009)
