摘要
目的观察三仁汤化裁联合红蓝光对脾胃湿热证痤疮的临床疗效。方法选取张掖人民医院皮肤科收治的196例脾胃湿热证痤疮患者,以密封信封法随机分为对照组和联合组,每组各98例。对照组采用红蓝光照射治疗,联合组采用三仁汤化裁联合红蓝光照射治疗,观察两组患者临床疗效、中医症状积分、血清生化指标、生活质量变化情况、不良反应和复发情况。结果治疗后联合组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗后两组中医症状积分(皮疹类型、皮损数量、皮疹形态和皮疹瘙痒)均显著降低,且联合组降低幅度更大,差异有统计学意义(P<0.05);治疗后两组血清的P物质、胰岛素样生长因子-1(IGF-1)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均显著降低,且联合组降低幅度更大,差异有统计学意义(P<0.05);治疗后两组痤疮患者特异性生活质量量表(Qol-Acne)中自我感知、情感功能、社会功能评分及总分均显著提高,且联合组治疗后自我感知、情感功能和总分显著高于联合组,差异有统计学意义(P<0.05);治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。随访3个月发现,联合组复发率显著低于对照组,差异有统计学意义(P<0.05)。结论三仁汤化裁联合红蓝光照射治疗较单纯红蓝光照射治疗疗效更好,且有助于缓解患者皮疹症状,调节机体相关的血清因子水平,提高患者生活质量并降低复发率。
BJECTIVE To observe the clinical efficacy of Sanren decotion huacai therapy combined with red-blue light on spleen-stomach damp-heat syndrome of acne.METHODS A total of 196 patients with spleen-stomach damp-heat syndrome of acne who were treated in the dermatology department of target hospital were selected and randomly divided into control group and combined group according to the sealed envelop method,with 98 cases in each group.Control group was treated with red-blue light irradiation,and combined group was given Sanren decotion huacai therapy combined with red-blue light irradiation.The clinical efficacy and TCM symptoms scores,serum biochemical parameters,quality of life,adverse reactions and recurrence were observed in these two groups.RESULTS After treatment,the total effective rate of treatment in combined group was significantly higher than control group(P<0.05).After treatment,the TCM symptoms scores(rash type,number of skin lesions,rash form,rash itching)were significantly decreased in the two groups,and the decreases were greater in combined group(P<0.05).After treatment,the serum levels substance P,insulin-like growth factor-1(IGF-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were significantly decreased in the two groups,and the decreases were greater in combined group(P<0.05).After treatment,the scores of self-perception,emotional function and social function and total score of specific quality of life scale for acne patients(Qol-Acne)were significantly improved in these two groups,and the scores of self-perception and emotional function and total score in combined group were significantly higher than the control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups during treatment(P>0.05).At 3 months of follow-up,the recurrence rate in combined group was significantly lower than that in control group(P<0.05).CONCLUSIOS Sanren decotion huacai therapy combined with red-blue light irradiation had better treatment efficacy than pure red-blue light irradiation,and it coould help alleviate the rash symptoms,regulate the levels of serum factors,improve the quality of life and reduce the recurrence rate.
作者
王婧
李巧林
张震
夏毓
韩磊
WANG Jing;LI Qiao-lin;ZHANG Zhen(Zhangye People’s Hospital Affiliated to Hexi University,Zhangye,Gansu,734000,China)
出处
《中国初级卫生保健》
2019年第4期89-91,共3页
Chinese Primary Health Care
关键词
三仁汤化裁
红蓝光
脾胃湿热证
痤疮
疗效
sanren decotion Huacai therapy
red-blue light
spleen-stomach damp-heat syndrome
acne
curative effect
