摘要
目的:探讨胰腺浆液性囊腺瘤(serous cystadenoma of the pancreas, SCAP)的临床与病理特征。方法:收集9例诊断为SCAP的临床资料,对其病理特征、特殊染色、免疫组化结果进行分析及相关文献复习。结果:本组8例患者均为女性,1例为男性,发病年龄为26～65岁,平均年龄为52岁。临床主要表现为不同程度的腹胀、腹痛。其中微囊型7例(占77.8%),寡囊型2例(占22.2%)。组织学上,囊壁由单层立方上皮衬覆,细胞相对一致,胞浆透明,核无异型性和无核分裂。免疫组化:EMA、CK7、CK8、CK18及CK19均(+),Ki-67 (+,1%～3%),CEA、Syn、P53及CgA均(-)。特殊染色:PAS (+)。结论:SCAP是胰腺外分泌腺罕见肿瘤,临床多无明显症状,诊断该病多依靠病理组织学检查,故准确掌握该病的病理特征十分重要。
Objective: To explore the clinicopathological features of serous cystadenoma of the pancreas (SCAP). Methods: We collected the clinical data of 9 cases diagnosed as SCAP, analyzed their pathological features, special staining results, and immunohistochemical results, and reviewed the relevant literature. Results: Eight patients were female and one was male. The age of patients ranged from 26 to 65 years, with a mean age of 52. The main clinical manifestations were varying degrees of abdominal distension and abdominal pain. Among the cases, 7 (77.8%) were microcystic adenoma and 2 (22.2%) were oligocystic adenoma. Histologically, the cyst wall is lined by a single layer of cuboidal epithelial cells, which were relatively uniform and had clear cytoplasm, with no nuclear atypia or division. The immunohistochemical results were as follows: EMA (+), CK7 (+), CK8 (+), CK18 (+), and CK19 (+);Ki-67 (+, 1%-3%);CEA (-), Syn (-), p53 (-), and CgA (-). PAS (+) was found in special staining. Conclusion: SCAP is a rare type of pancreatic exocrine gland tumor. A lack of obvious clinical symptoms makes the diagnosis dependent on histopathological examination. So it is essential to master the accurate pathological features of this disease.
作者
唐月阳
夏天
刘俊
叶入裴
肖秀丽
龙汉安
TANG Yueyang;XIA Tian;LIU Jun;YE Rupei;XIAO Xiuli;LONG Hanan(Department of Pathology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China)
出处
《西南医科大学学报》
2019年第2期143-147,共5页
Journal of Southwest Medical University
基金
泸州市政府-泸州医学院联合专项(2013LZLY-J28)
四川省科技厅项目(LY-55)
