摘要
目的分析肾移植受者HLA-A、B、DR和DQ抗原分布频率。方法收集2017年1月至2018年6月在解放军总医院第八医学中心接受肾移植的791例受者HLA抗原检测数据,分析HLA-A、B、DR和DQ抗原种类和分布频率。结果 HLA-A抗原共出现18种,其中A2、A11和A24(9)抗原分布频率较高,分别为30.59%、17.83%和15.68%;A2403、A34(10)和A66(10)抗原分布频率最低,均为0.06%。HLA-B抗原共出现42种,其中分布频率最高的是B13(12.64%),分布频率最低的是B44、B41和40∶40(均为0.06%)。HLA-DR抗原共出现16种,其中DR15(2)、DR4和DR12(5)分布频率较高,分别为14.60%、13.65%和13.40%;DR6分布频率最低(0.19%);DR15(2)与DQ6(1)具有强连锁反应(90.48%)。HLA-DQ抗原共出现7种,DQ7(3)抗原分布频率最高(24.91%),DQ8(3)分布频率最低(5.50%)。结论肾移植受者HLA-A、B、DR和DQ抗原中,A2、B13、DR15(2)和DQ7(3)分别为分布频率最高的抗原。分析HLA抗原分布频率有利于寻找HLA匹配的供者。
Objective To analyze the distribution frequency of HLA- A, B, DR and DQ antigens in patients waiting for renal transplantation. Methods The HLA antigens detection data of 791 recipients who recieved renal transplantation in the Organ Transplantation Department, Eighth Medical Center, General Hospital of the PLA during January 2017 and June 2018 were collected, and then the distribution frequencies of HLA- A, B, DR and DQ antigens were analyzed. Results There were 18 types of HLA- A antigens, among which the distribution frequencies of A2, A11 and A24 (9)(30.59%, 17.83% and 15.68%, respectively ) were higher than other HLA- A antigens, and the distribution frequencies of A2403, A34 (10) and A66 (10) were the lowest, all of which were 0.06%. There were 42 types of HLA- B antigens, among which B13 (12.64%) had the highest distribution frequencies (12.64%), and the distribution frequencies of B44, B41 and 40 ∶ 40 were the lowest, all of which were 0.06%. There were 16 types of HLA- DR antigens, among which DR15 (2), DR4 and DR12(5) had higher distribution frequencies (14.60%, 13.65% and 13.40%, respectively), and DR6 had the lowest distribution frequency (0.19%) and DR15 (2) had strong linkage reaction with DQ6 (1)(90.48%). There were 7 types of HLA- DQ antigens, DQ7(3) had the highest distribution frequency (24.91%) and DQ8(3) had the lowest distribution frequency (5.50%). Conclusions Among HLA- A, B, DR and DQ antigens in renal transplantation recipients, A2, B13, DR15 (2) and DQ7 (3) are the most frequently distributed antigens. Distribution frequency analysis of HLA antigens is helpful to find HLA matching donors.
作者
马锡慧
肖漓
韩永
孙玉洁
傅凌云
刘培霞
石炳毅
Ma Xihui;Xiao Li;Han Yong;Sun Yujie;Fu Lingyun;Liu Peixia;Shi Bingyi(Basic Research Laboratory of Organ Transplant Institute,Eighth Medical Center,General Hospital of the Chinese People′s Liberation Army,Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory,Beijing 100091,China)
出处
《中华移植杂志（电子版）》
CAS
2019年第1期50-53,共4页
Chinese Journal of Transplantation(Electronic Edition)
基金
国家自然科学基金(81571555)
解放军第三○九医院面上课题(2016MS-002)
关键词
肾移植
HLA抗原
分布频率
等位基因
基因多态性
Renal transplantation
HLA antigen
Distribution frequency
Allele
Gene polymorphism
