摘要
目的探讨血清C反应蛋白(CRP)、可溶性细胞间黏附分子1(sICAM-1)、脂蛋白相关磷脂酶A2(Lp-PLA2)、视黄醇结合蛋白4(RBP4)与冠状动脉粥样硬化(AS)的关系及对冠状动脉粥样硬化性心脏病(冠心病,CHD)的诊断价值。方法选取2015年1月至2016年12月于郑州大学第一附属医院确诊的冠心病患者160例为CHD组,其中稳定型心绞痛(SAP)50例、不稳定型心绞痛(UAP)70例、急性心肌梗死(AMI)40例、另选40例健康对象作为对照组,检测各组血清CRP、sICAM-1、Lp-PLA2、RBP4及一般生化指标水平并进行对比分析。结果 CHD组和对照组的血清sICAM-1、RBP4水平差异无统计学意义(P>0.05),CHD组的血清CRP、Lp-PLA2显著低于对照组(P<0.05);SAP、UAP、AMI患者的血清sICAM-1、RBP4水平差异无统计学意义(P>0.05),SAP、UAP、AMI患者的血清CRP、Lp-PLA2呈逐渐升高的趋势,差异有统计学意义(P<0.05);不同冠状动脉(冠脉)病变支数患者的血清sICAM-1、RBP4水平差异无统计学意义(P>0.05),单支、双支、三支患者的血清CRP、Lp-PLA2呈逐渐升高的趋势,差异有统计学意义(P<0.05);冠心病患者的血清CRP、Lp-PLA2与患者Gensini呈显著正相关性(P<0.05)。结论血清CRP、Lp-PLA2对于诊断冠心病具有一定的临床意义,同时与冠心病患者冠状动脉粥样硬化病变程度具有相关性。
Objective To investigate the relationship among C-reactive protein(CRP),soluble intercellular adhesion molecule-1(sICAM-1),lipoprotein associated phospholipase A2(Lp-PLA2),retinol binding protein 4(RBP4)and coronary atherosclerosis(AS),and discuss it diagnostic value to coronary heart disease(CHD).Methods CHD patients(n=160,CHD group)were chosen from the First Affiliated Hospital of Zhengzhou University from Jan.2015 to Dec.2016,among them there were 50 cases of stable angina pectoris(SAP subgroup),70 of unstable angina pectoris(UAP subgroup)and 40 of acute myocardial infarction(AMI subgroup),and other 40 cases of healthy controls were chosen into control group.The levels of serum CRP,sICAM-1,Lp-PLA2,RBP4 and general biochemical indexes were detected,compared and analyzed in all groups.Results The levels of sICAM-1 and RBP4 had no statistical difference between CHD group and control group(P>0.05),and levels of CRP and Lp-PLA2 were significantly lower in CHD group than those in control group(P<0.05).The levels of sICAM-1 and RBP4 had no statistical difference among SAP subgroup,UAP subgroup and AMI subgroup(P>0.05),and levels of CRP and Lp-PLA2 showed a gradual increasing trend in 3 subgroups(P<0.05).The levels of sICAM-1 and RBP4 had no statistical difference(P>0.05),and levels of CRP and Lp-PLA2 showed a gradual increasing trend(P<0.05)in patients with 1-vessel lesion,2-vessel lesion or 3-vessel lesion of coronary artery.The levels of serum CRP and Lp-PLA2 were significantly correlated to Gensini scores in CHD patients(P<0.05).Conclusion The levels of serum CRP and Lp-PLA2 have some clinical significance in CHD diagnosis and meanwhile are correlated to lesion severity of coronary AS.
作者
林彬
徐敬
王佳祥
李莉
赵晖
冯德广
Lin Bin;Xu Jing;Wang Jiaxiang;Li Li;Zhao Hui;Feng Deguang(Department of Heart and Great Vessel Surgery,First Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou450018,China)
出处
《中国循证心血管医学杂志》
2019年第2期227-229,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
