摘要
目的分析血清鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)和人附睾上皮分泌蛋白4(HE4)联合检测在宫颈癌诊断中的临床价值。方法选取2015年12月至2017年12月在我院确诊的宫颈癌患者78例为宫颈癌组,宫颈良性疾病患者80例为良性疾病组。同时选取同期在我院接受体检的80例健康女性作为对照组,采用电化学发光法和酶联免疫吸附法检测3组研究对象血清SCC-Ag、CEA、CYFRA21-1及HE4水平。分析4种检测指标单独及联合检测在宫颈癌诊断中的意义。结果宫颈癌组患者血清SCC-Ag、CEA、CYFRA21-1及HE4水平显著高于良性疾病组与对照组,差异具有统计学意义(P <0. 05)。宫颈癌组单项指标检测的阳性率均显著高于良性疾病组与对照组;且宫颈癌组4项指标联合检测阳性率均显著高于单项指标检测结果 ,差异具有统计学意义(P <0.05)。SCC-Ag、CEA、CYFRA21-1及HE4联合诊断宫颈癌的灵敏度和准确度为88. 46%、87. 82%,显著高于单项指标检测结果 (P<0.05)。结论血清SCC-Ag、CEA、CYFRA21-1及HE4联合检测可有效提高宫颈癌诊断的灵敏度和准确度,具有较高的临床参考价值。
Objective To analyze the clinical values of serum squamous cell carcinoma antigen (SCC-Ag),carcinoembryonic antigen (CEA),cytokeratin 19 fragment (CYFRA21-1) and human epididymal epithelial secretory protein 4 (HE4) in the diagnosis of cervical cancer.Methods 78 patients with cervical cancer diagnosed in our hospital from December,2015 to December,2017 were selected as the cervical cancer group,while 80 patients with benign cervical diseases were selected as the benign disease group.At the same time,80 healthy women who underwent physical examinations in our hospital were selected as the control group.The levels of serum SCC-Ag,CEA,CYFRA21-1 and HE4 in the three groups were detected by electrochemiluminescence and enzyme-linked immunosorbent assay.The significances of the four detection indicators alone or in combination in the diagnosis of cervical cancer were then analyzed.Results The levels of serum SCC-Ag,CEA,CYFRA21-1 and HE4 in the cervical cancer group were significantly higher than those in the benign disease group and the control group (P <0.05).The positive rate of single index detection in the cervical cancer group was significantly higher than that in the benign disease group and the control group,and the positive rate of combined detection of four indicators was significantly higher than that of single marker index in the cervical cancer group (P <0.05).The sensitivity and accuracy of SCC-Ag,CEA,CYFRA21-1 and HE4 in combination in the diagnosis of cervical cancer were 88.46% and 87.82%,respectively,which were significantly higher than those of single marker index (P <0.05).Conclusion The combined detection of serum SCC-Ag,CEA,CYFRA21-1 and HE4 can effectively improve the sensitivity and accuracy of cervical cancer diagnosis,which has a high clinical reference value.
作者
王玉婧
查毅
WANG Yu-jing;CHA Yi(Department of Clinical Laboratory,Sichuan Jinxin Women and Children's Hospital,Chengdu 610011,China;Department of Clinical Laboratory,Chengdu Public Health Clinical Medical Center,Chengdu 610011,China)
出处
《标记免疫分析与临床》
CAS
2019年第4期637-640,共4页
Labeled Immunoassays and Clinical Medicine
关键词
宫颈癌
联合检测
血清鳞状细胞癌抗原
肿瘤标志物
Cervical cancer
Combined detection
Serum squamous cell carcinoma antigen
Tumor marker
