摘要
目的分析艾灸联合阿司匹林对老年冠心病患者血小板聚集功能的影响及其抑制率分析。方法收集2016年9月至2018年4月100例老年冠心病患者,随机数字表法分为观察组和对照组。评估心功能治疗效果,观察心功能指标[左心室射血分数(LVEF)、每分输出量(CO)、血浆脑自然肽氨基端前体蛋白(NT-proBNP)],记录2组患者治疗前后二碳酸腺苷(ADP)、花生四烯酸(AA)诱导血小板聚集率和GMP-140分子数。结果观察组心功能治疗总有效率(90.00%)较对照组(78.00%)高,差异有统计学意义(P<0.05)。治疗后观察组LVEF、CO提高,NT-proBNP降低,差异有统计学意义(P<0.05);心率变化差异无统计学意义(P>0.05)。治疗后对照组心率、NT-proBNP降低,CO、LVEF升高,差异有统计学意义(P<0.05)。治疗后观察组上述指标均较对照组优,差异有统计学意义(P<0.05)。治疗前2组AA途径、ADP途径下血小板聚集及GMP-140分子数比较差异无统计学意义(P>0.05);治疗后2组A途径、ADP途径下血小板抑制率及GMP-140分子数均降低,且观察组较对照组低,差异有统计学意义(P<0.05)。结论艾灸联合阿司匹林治疗老年冠心病能改善心功能和血小板聚集功能和抑制率,值得推广。
Objective To analyze the effects of moxibustion combined with aspirin on the function of platelet aggregation in elderly patients with coronary heart disease and its inhibition rate. Methods A total of 100 elderly patients with coronary heart disease who were treated in our hospital from September 2016 to April 2018 were divided into observation group and control group according to the random number table. The therapeutic effects,and the cardiac function indexes including left ventricular ejection fraction (LVEF), cardial output per minute (CO), plasma brain natriuretic peptide amino terminal precursor protein (NT proBNP) were observed and compared between the two groups,moreover the platelet aggregation rate and the numbers of GMP 140 molecules induced by adenosine diphosphate (ADP) and arachidonic acid (AA) before and after treatment in both groups were recorded. Results The total effective rate of cardiac function in observation group was significantly higher than that in control group (90.00% vs 78.00%, P <0.05). After treatment, the levels of LVEF and CO in observation group were significantly increased,as compared with those before treatment, however the plasma levels of NT proBNP were significantly decreased ( P <0.05),there was no significant change in heart rate in observation group before and after treatment ( P >0.05).After treatment, the heart rate, plasma levels of NT proBNP in control group were significantly decreased,however,the levels of CO and LVEF were significantly increased ( P <0.05). After treatment the indexes above in observation group were superior to those in control group ( P <0.05). Before treatment there were no significant differences in platelet aggregation and the numbers of GMP 140 moleculus by AA pathway and ADP pathway between the two groups ( P >0.05). After treatment the platelet inhibition rate and the numbers of GMP 140 molecules by AA pathway and ADP pathway were significantly decreased in both groups,moreover,which in observation group were significantly lower than those in control group ( P <0.05). Conclusion Moxibustion combined with aspirin can improve cardiac function, aggregation function and inhibition rate of platelet in elderly patients with coronary heart disease, therefore,which is worthy of promotion in clinical practice.
作者
左静
刘虹
李金涛
王学杰
叶锋
ZUO Jing;LIU Hong;LI Jintao(Department of Cardiology,People’s Hospital of Huanghua City,Hebei,Huanghua 061100,China)
出处
《河北医药》
CAS
2019年第7期1043-1045,1050,共4页
Hebei Medical Journal
关键词
艾灸
阿司匹林
老年冠心病
血小板聚集功能
血小板抑制率
moxibustion
aspirin
senile coronary heart disease
platelet aggregation function
platelet inhibition rate
