摘要
本文介绍了核磁共振氢谱在阿司匹林合成实验中的应用,学生查阅相关文献,自主设计合成路线,并通过核磁共振氢谱对原料、粗产物、精制产物定性表征以及定量分析,实现有机波谱理论和药物合成实验的结合,激发学生学习兴趣,培养学生科研能力,对改进教学效果具有重要意义。
The application of nuclear magnetic resonance spectroscopy in the synthesis of aspirin was introduced. Students were consulted with relevant literature and self-designed synthetic routes. The qualitative characterization and quantitative analysis of raw materials, crude products and refined products by nuclear magnetic resonance spectroscopy were realized. The combination of spectral theory and drug synthesis experiments have stimulated students’ interest in learning and cultivated students’ scientific research ability, which is of great significance for improving the teaching quality.
作者
刘长青
薛洪宝
李文戈
LIU Chang-qing;XUE Hong-bao;LI Wen-ge(Department of Drug Synthesis, Bengbu Medical College, Bengbu Anhui 233030, China)
出处
《长春师范大学学报》
2019年第4期73-75,99,共4页
Journal of Changchun Normal University
基金
安徽省高等教育振兴计划重大教学改革研究项目"工程教育专业认证背景下制药工程专业创新人才培养教学改革研究"(2015zdjy101)
安徽省教学质量工程重大项目"面向新工科建设的青年教师培养模式改革与创新研究"(2017jyxm0248)
关键词
核磁共振氢谱
阿司匹林
应用策略
nuclear magnetic resonance hydrogen spectroscopy
aspirin
application strategy
