摘要
目的:对多巴胺(Dopamine;DA)和去甲肾上腺素(Norepinephrine;NE)治疗感染性休克的临床效果进行对比研究。方法:收集整理在临床工作中30例感染性休克患者,按编号随机抽签的方法分为对照组与试验组,各组有15例,对照组采用DA治疗,试验组采用NE进行治疗,观察用药前后两组患者相关指标变化程度,把收集的相关指标数据作统计学处理。结果:试验组心律失常的发生率要明显低于对照组,试验组的有效循环血量、组织灌注、组织细胞缺氧纠正效果明显优于对照组,两组之间差异具有统计学意义(P<0.05)。结论 :DA和NE均能有效治疗感染性休克,纠正组织细胞缺氧,而NE纠正组织缺氧和改善微循环灌注更优于DA,并且心律失常发生率低,值得临床推广应用。
Objective To compare the clinical effects of dopamine and norepinephrine in the treatment of septic shock.Method 30 patients with septic shock during clinical work were collected,and number them.They were randomly divided into control group and experimental group with each group 15 cases by the method of random lottery by number.To use dopamine for the control group and norepinephrine for the experimental group,and then the changes of the relevant indicators between the two groups before and after the treatment were observed,and to collect these data of relevant indicators for statistical analysis.Results The rate of arrhythmia in the experimental group was significantly lower than that in the control group,and the effective circulating blood volume,tissue perfusion and hypoxia correction of tissue cells in the experimental group were significantly better than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion Both dopamine and norepinephrine can effectively treat septic shock via correcting tissue cell hypoxia.However,norepinephrine is better than dopamine in correcting tissue hypoxia and improving microcirculation perfusion,also the incidence of arrhythmia is much lower by using norepinephrine,therefore,norepinephrine is worthy of widely clinical application.
作者
游从银
YOU Cong-dn(The people's hospital of Dazhu County,Dazhou City,Dazhu 633100,China)
出处
《吉林医学》
CAS
2019年第4期762-763,共2页
Jilin Medical Journal
