摘要
香菇多糖是从真菌香菇的子实体中分离出来的,主要成分为β-1,3-葡聚糖,是一种具有免疫调节作用及抑制肿瘤生长的生物调剂节,主要用于肿瘤的辅助治疗,在增强放化疗疗效、减轻放化疗毒副作用、提高机体免疫力和改善预后等方面发挥作用,在临床上取得了较好的疗效,目前在国内外被广泛应用和深入研究。因此,对香菇多糖在免疫调节,抑制肿瘤细胞增殖,诱导肿瘤细胞凋亡、自噬,抑制肿瘤细胞血管生成及肿瘤细胞上皮间质转化,以及新型纳米材料联合应用等方面的作用进行综述,为研究香菇多糖抗肿瘤作用及机制提供新的思路。
Lentinan(LNT) is isolated from the fruiting body of fungus Lentinus edodes. The main active ingredient is β-1,3-glucan,which has pivotal role in modulating immune response and inhibiting tumor cell growth. It has been widely applied in clinic for adjuvant antitumor therapy in increasing the efficacy of radiotherapy and chemotherapy, reducing toxic and side effects of antitumor therapy, and improving the body immunity and prognosis. LNT has achieved good curative effect in clinic, and it is widely used and deeply studied at home and abroad. This review aims to discuss the progress on the role of LNT in terms of immune modulation,inhibition of tumor cell proliferation, induction of apoptosis and autophagy of tumor cells, inhibition of tumor angiogenesis and epithelial-mesenchymal transition(EMT), and the antitumor effect of compound of lentinan combined with multi-walled carbon nanotube(WMWCN) and antitumor drug, which could provide scientific reference for its future research related to the mechanism underlying the antitumor activity of lentinan.
作者
苏畅
李小江
贾英杰
张晶
SU Chang;LI Xiao-jiang;JIA Ying-jie;ZHANG Jing(Department of Oncology, The First Teaching Hospital ofTianjin University of Traditional Chinese Medicine, Tianjin 300193, China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第6期1499-1504,共6页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目"基于IRF3/IFN通路探讨香菇多糖联合IRF3腺病毒载体的抗乳腺癌作用及机制研究"(81503392)
关键词
香菇多糖
肿瘤免疫
免疫调节
细胞凋亡
自噬
lentinan
tumor immunity
immunomodulation
cell apoptosis
autophagy
