摘要
目的:探讨短期二甲双胍治疗对肥胖合并NAFLD患者微炎症反应及氧化应激反应的影响。方法:选择我院收治的肥胖合并NAFLD患者进行回顾性研究,分为接受常规治疗的对照组和接受常规治疗联合短期二甲双胍治疗的二甲双胍组。治疗前及治疗后2周,测定血清中炎症因子及氧化应激指标的含量。结果:两组治疗前血清中炎症因子、氧化应激指标的比较无显著性差异。治疗2周,两组血清中IL-1β、IL-6、IL-18、IL-33、AOPPs、ROS、LHP的含量均降低,SOD、T-AOC的含量均升高且二甲双胍组血清中IL-1β、IL-6、IL-18、IL-33、AOPPs、ROS、LHP的含量低于对照组,SOD、T-AOC的含量高于对照组。结论:肥胖合并NAFLD患者接受短期二甲双胍治疗,可有效抑制机体微炎症状态并减轻氧化应激反应。
Objective:To explore the effect of short-term metformin therapy on micro-inflammatory response and oxidative stress response in obese patients with NAFLD.Methods:obese patients with NAFLD who received treatment in our hospital between March 2014 and January 2018 were selected for retrospective study and divided into control group receiving conventional therapy and the metformin group receiving conventional therapy combined with short-term metformin therapy.Before treatment and 2 weeks after treatment,serum levels of inflammatory factors and oxidative stress indexes were measured.Results:Before treatment,there was no significant difference in serum levels of inflammatory factors or oxidative stress indexes between the two groups.After 2 weeks of treatment,the serum levels of IL-1β,IL-6,IL-18,IL-33,AOPPs,ROS and LHP of both groups decreased,while the levels of SOD and T-AOC increased and the serum levels of IL-1β,IL-6,IL-18,IL-33,AOPPs,ROS and LHP of observation group were lower than those of control group,while the levels of SOD and T-AOC were higher than those of control group.Conclusion:Short-term metformin can effectively inhibit the micro-inflammatory state and reduce the oxidative stress response in obese patients with NAFLD.
作者
王坤
沈俐萍
WANG Kun;SHEN Li-ping(Department of Endocrinology,Zigong First People's Hospital in Sichuan Province,Zigong,Sichuan Province,643000,China;Department of Thyroid,Breast and Vascular Surgery,Zigong First People's Hospital in Sichuan Province,Zigong,Sichuan Province,643000,China)
出处
《海南医学院学报》
CAS
2019年第8期602-605,共4页
Journal of Hainan Medical University
基金
四川省医学科研青年创新课题计划(Q15090)~~
关键词
非酒精性脂肪性肝病
肥胖
二甲双胍
炎症反应
氧化应激反应
Non-alcoholic fatty liver disease
Obesity
Metformin
Inflammatory response
Oxidative stress response
