摘要
目的:探讨精索静脉曲张(varicocele,VC)病人血清8-羟基脱氧鸟苷(8-hydroxy-2′-deoxyguanosine,8-OHdG)水平的临床价值。方法:选取行精索静脉高位结扎术治疗的VC病人30例,测量术前和术后3个月的血清8-OHdG水平,比较手术前后的差异,并分析其水平与单、双侧发病、精索静脉宽度的相关。结果:术前,VC单侧组与双侧组血清8-OHdG水平差异无统计学意义(P>0.05),不同精索静脉宽度病人血清8-OHdG水平差异无统计学意义(P>0.05)。30例病人术后血清8-OHdG水平为(261.64±82.55)pg/mL,较术前的(327.20±101.86)pg/mL明显降低(P<0.01)。结论:作为一项氧化应激的指标,血液中8-OHdG水平的升高与VC导致的不育相关,且其水平的降低对于行手术治疗的VC病人预后的判断,有一定的临床意义。
Objective: To investigate the clinical value of the serum level change of 8- hydroxy-2′-deoxyguanosine(8-OHdG) in varicocele(VC) patients. Methods: The serum levels of 8-OHdG in 30 VC patients treated with high spermatic vein ligation were measured before and after 3 months of surgery.The differences of the serum levels of 8-OHdG between before and after surgery were compared,and the correlations of the level of 8-OHdG with incidence rate of single or bilateral VC and width of spermatic vein were analyzed. Results: Before surgery,there was no statistically significant in the serum level of 8-OHdG between the VC unilateral group and bilateral group( P >0.05),and there was no statistical significance in the serum levels of 8-OHdG level among patients with different widths of spermatic vein( P >0.05).The postoperative 8-OHdG level[(261.64±82.55)pg/mL] was significantly lower than that of preoperative level[(327.20±101.86)pg/mL] in 30 patients( P <0.01). Conclusions: The serum level of 8-OHdG increasing,an indicator of oxidative stress,is related to the infertility caused by VC,and the level of 8-OHdG decreasing has a certain clinical significance in judging the prognosis of VC patients treated with operation.
作者
徐鹏琛
孙超
XU Peng-chen;SUN Chao(School of Graduate,Bengbu Medical College,Bengbu Anhui 233030;Department of Urology,The Third People′s Hospital of Bengbu,Bengbu Anhui 233000,China)
出处
《蚌埠医学院学报》
CAS
2019年第3期350-352,共3页
Journal of Bengbu Medical College
基金
蚌埠医学院科研课题计划项目(BYKY16148)
