摘要
目的通过比较济宁地区以医院为基础和以人群为基础的原发性食管癌发病因素病例对照研究结果的差异,以发现和控制病例对照研究中的选择性偏倚,进一步验证相关因素与食管癌的关联性。方法采用双重1∶1配对的病例对照研究,纳入152例病例组、152例医院对照组和152例人群对照组为研究对象,对食品卫生与饮食习惯、饮用水情况、吸烟与饮酒情况、家族与职业史和心理社会应激情况进行问卷调查,将数据用Epi Data3.0软件进行录入,运用SPSS18.0统计软件进行条件logistic回归分析。结果以医院为基础和以人群为基础的病例对照研究中,常吃烫热食品(OR_(病例vs医院对照)=4.335,P=0.000; OR_(病例vs人群对照)=2.722,P=0.000)、食用棉籽油(OR_(病例vs医院对照)=4.200,P=0.000; OR_(病例vs人群对照)=3.700,P=0.000)与食管癌发病有较大的相关性,其次为食用腌制食品、供水方式、水源受到污染、生活事件,而饮用井水、不储水和积极情绪体验对食管癌的发病起保护作用,以上因素在两种对照结果中均具有统计学意义。多因素分析中食用烫热食品、供水方式、水源类型、食用豆油表现出相关的一致性。心理应激评分中发现"生活事件"L因子和"消极应对"NC因子两种对照均具有统计学意义。结论食管癌以医院和以人群为基础的病例对照研究中,食管癌与常吃烫热食品、食用棉籽油等11个相关影响因素的关联性均同时存在。
Objective To find and control the selective bias of the case-control study on primary esophageal cancer in Jining region by comparing the differences results on the hospital-based and population-based case-control study,so as to verify the relevance the related factors and esophageal cancer. Methods A double 1 ∶1 matched case-control study was used,including 152 esophageal cancer patients,152 hospital-based controls and 152 population-based controls.Questionnaire survey was conducted to investigate food health and diet,water,smoking,drinking,family history,history of career and psychosocial stress situation.We used EpiData3.0 for data entry and SPSS18.0 for statistical analysis. Results There were significant relationship between frequent eating hot food( OR case VS hospital control =4.335, P =0.000;OR case VS people control =2.722, P =0.000),eating cottonseed oil( OR case VS hospital control =4.200, P =0.000;OR case VS people control =3.700, P =0.000)and esophageal cancer.Pickled food,water supply way,the pollution water and living incident has the closed correlation with the incidence of esophageal cancer,and well water,no water storage and PE are protective factors.The above factors in the two control ways were statistically significant.Eating hot food,drinking well water and eating soya-bean oil showed the consistency at multiple factors analysis.At psychological stress score,life events L,negative coping NC,both types of contrast were statistically significant. Conclusion Esophageal cancer was a variety of environmental and psychological factors on the individual long-term repeated with different genetic predisposition result,comprehensive prevention and control measures should be adopted.
作者
李英娥
翟敏
王猛
崔平
刘苗苗
郭立燕
LI Yinge;ZHAI Min;WANG Meng;CUI Ping;LIU Miaomiao;GUO Liyan(School of Public Health,Jining Medical University,Jining 272013,China)
出处
《济宁医学院学报》
2019年第2期95-100,共6页
Journal of Jining Medical University
基金
山东省医药卫生科技计划项目(2011HZ015)
济宁医学院科研计划重点项目(JY2013KJ001)
