摘要
目的分析广州地区妊娠期妇女的碘营养状况,探讨其与甲状腺功能减退的关系。方法随机选取2017年1～12月于广州市妇女儿童医疗中心产科门诊进行产检的孕妇4 986例,对其空腹血清促甲状腺激素(TSH)、游离甲状腺激素(FT4)、甲状腺过氧化物酶抗体(TPOAb)及尿碘(UI)水平进行回顾性分析。结果 4 896例孕妇尿碘水平为5～1 476μg/L,中位数为179.3μg/L,碘缺乏、碘适量、碘超足量和碘过量的发生率分别为39.93%,28.42%,18.99%和12.66%。随着尿碘水平的升高,TSH和FT4水平随之升高,差异具有统计学意义(χ~2=20.19,P=0.001;χ~2=16.45,P=0.000);三组甲状腺功能异常在不同碘营养状态的发生率差异无统计学意义(χ~2=4.08,P=0.67);TPOAb的阳性率为24.11%,其在三组甲状腺疾病中的阳性率差异具有统计学意义(χ~2=10.18,P=0.006)。结论广州地区妊娠期碘不足或碘过量较为常见,维持适量的尿碘水平对预防甲状腺功能异常有重要意义。
Objective To investigate the association of urinary iodine nutritional of pregnant women with hypothyroidism in Guangzhou.Methods A total of 4 986pregnant women were enrolled from January 2017to December,and retrospectively analyzed their urinary iodine level(UI)and thyroid function index(included TSH,FT4and TPOAb).Results The range of urine iodine level in pregnant women was 5~1 476μg/L,the urine iodine median was 179.3μg/L,the iodine deficiency,iodine in moderation,iodine adequate enough,and the incidence of iodine excess were 39.93%,28.42%,18.99%and 12.66%,respectively.With the increase of urinary iodine,the levels of TSH and FT4increased,and the difference was statistically significant(χ^2=20.19,P=0.001;χ^2=16.45,P=0.000).The incidence of hypothyroidism,subclinical hypothyroidism and low thyroid hormone levels were 0.14%,0.62%and 2.05%,respectively.Compared three groups of thyroid disease incidence in different urinary iodine levels,there was no statistically significant(χ^2=4.08,P=0.67).The positive rate of TPOAb was 24.11%,and compared the positive rate of TPOAb between three group thyroid disease,there was statistically significant(χ^2=10.18,P=0.006).Conclusion Iodine deficiency or excess during pregnancy is common in Guangzhou.Maintaining adequate urinary iodine level is of great significance in preventing thyroid dysfunction.
作者
陈小娟
邱敏娟
高飞
李飞
郑浩
蔡敏敏
CHEN Xiao-juan;QIU Min-juan;GAO Fei;LI Fei;ZHENG Hao;CAI Min-min(Department of Clinical Laboratory,Zhujiang New Town,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China;Department of Prenatal Diagnosis,Guangzhou Women and Children’s Medical Center,Guangzhou 510623,China)
出处
《现代检验医学杂志》
CAS
2019年第2期119-121,124,共4页
Journal of Modern Laboratory Medicine
关键词
妊娠
尿碘
甲状腺功能
pregnancy
urinary iodine
thyroid function
