摘要
目的:分析389例前列腺癌和前列腺增生的血清睾酮水平、血脂及相关指标,探索血清睾酮水平及高脂血症与前列腺癌之间的内在关系。方法:回顾性研究2014年1月至2018年3月我院泌尿外科就诊行前列腺穿刺活检或者行前列腺电切术符合本研究的病例389例,其中前列腺癌117例,前列腺增生272例,合并高脂血症患者137例;收集患者的年龄、游离前列腺特异抗原(free prostate specific antigen,f PSA)、血清总前列腺特异抗原(total prostate specific antigen,TPSA)、f/PSA、血清睾酮、前列腺体积(prostate volume,PV)、病理结果,采用logistic回归模型对前列腺癌组和前列腺增生组进行病例对照研究。结果:多因素logistic回归分析显示前列腺癌组和前列腺增生组年龄、TPSA、f/PSA、PV比较差异存在统计学意义(P<0.05),而f PSA、血清睾酮2组比较无统计学意义(P>0.05)。低睾酮组和高睾酮组前列腺癌与前列腺增生的比较中,睾酮值在2组间均无统计学差异(P>0.05)。高脂血症患者中,多因素logistic回归分析显示胆固醇在前列腺癌与前列腺增生组比较差异存在统计学意义(P<0.05),甘油三酯、高密度脂蛋白血症比较无统计学意义(P>0.05)。结论:血清睾酮水平与前列腺癌发病风险之间尚无明确关系,低睾酮水平患者高胆固醇血症可能会增加前列腺癌发病风险。
Objective:To explore the relationship between serum testosterone levels and hyperlipidemia and prostate cancer serum testosterone levels,by analyzing blood lipids and related indicators in 389 cases of prostate cancer and benign prostatic hyperplasia.Methods:Retrospective analysis was conducted in 389 cases of prostate biopsy or prostatectomy from January 2014 to March 2018.There were 117 cases of prostate cancer and 272 cases of benign prostatic hyperplasia,including 137 cases of hyperlipidemia. The data of age,free prostate specific antigen(f PSA),total prostate specific antigen(TPSA),f/PSA,serum testosterone,prostate volume(PV),and pathological diagnosis were collected. The study group was prostate cancer and thecontrol group was benign prostatic hyperplasia.Results:There were significant differences in age,TPSA,f/PSA and PV between the prostate cancer group and the benign prostatic hyperplasia group(P<0.05). There was no significant difference between f PSA and serum testosterone(P>0.05). In the low testosterone group and high testosterone group,there was no significant difference in testosterone between the two groups(P>0.05). Among patients with hyperlipidemia,there was a statistically significant difference in hypercholesterolemia between prostate cancer and benign prostatic hyperplasia(P < 0. 05). There was no statistically significant difference between high triglyceride and low-high density lipoprotein(P>0.05). Conclusion:There is no clear relationship between serum testosterone levels and the risk of prostate cancer.Hypercholesterolemia may increase the risk of prostate cancer.
作者
向针嵩
胡自力
刘川
张俊勇
雷雨声
吴昊
刘念
Xiang Zhensong;Hu Zili;Liu Chuan;Zhang Junyong;Lei Yusheng;Wu Hao;Liu Nian(Department of Urology,the Second Affiliaied Hospital of Chongqing Medical University)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2019年第3期360-364,共5页
Journal of Chongqing Medical University
