摘要
目的观察经颅磁刺激维持治疗复发性抑郁症的效果及其对患者认知功能的影响。方法将新会区第三人民医院2017年1月至2018年6月收治的80例复发性抑郁症患者作为研究对象,按随机数表法分为对照组和观察组,每组40例。对照组给予常规药物治疗,观察组在上述治疗基础上,给予经颅磁刺激维持治疗。治疗6周后,比较两组患者的治疗效果、治疗前及治疗6周后的威斯康星卡片分类测验(WCST)、应用持续操作测验(CPT)及不良反应情况。结果观察组患者的治疗总有效率为87.5%,明显高于对照组的72.5%,差异有统计学意义(P<0.05);治疗前,两组患者的总正确数、正确分类数、总错误数、持续错误数及非持续错误数等执行功能比较,差异均无统计学意义(P>0.05);治疗后,两组患者的总正确数、正确分类数明显升高,观察组分别为(33.23±10.29)个、(4.06±2.41)个,明显高于对照组的(27.09±9.82)个、(3.21±2.07)个,差异均有统计学意义(P<0.05);而总错误数、持续错误数及非持续错误数显著下降,观察组分别为(14.86±10.27)个、(4.77±3.80)个和(10.34±7.69)个,明显低于对照组的(20.91±9.82)个、(8.35±4.87)个和(12.56±7.08)个,差异均有统计学意义(P<0.05);治疗前后,两组患者的CPT1、CPT2及CPT3等注意力指标比较差异均无统计学意义(P>0.05);观察组患者的不良反应发生率为5.0%,明显低于对照组的22.5%,差异有统计学意义(P<0.05)。结论经颅磁刺激维持治疗复发性抑郁症患者效果显著,其可明显改善患者抑郁状况,减少并发症,安全可靠,在临床中值得推广应用。
Objective To observe the effect of transcranial magnetic stimulation maintenance in patients with recurrent depression and its influence on cognitive function of the patients.Methods Eighty patients with recurrent depression admitted to the Third People's Hospital of Xinhui District of Jiangmen from January 2017 to June 2018 were divided into a control group and an observation group according to random number table,with 40 patients in each group. The control group was given routine drug treatment,while the observation group was given transcranial magnetic stimulation maintenance treatment on the basis of routine drug treatment.After 6 weeks of treatment,the therapeutic effect, Wisconsin Card Classification Test (WCST),Continuous Operational Test (CPT),and adverse reactions were compared between the two groups before and after 6 weeks of treatment.Results The total effective rate of the observation group was 87.5%,which was significantly higher than 72.5% of the control group (P<0.05).Before treatment,there was no significant difference in the total correct number,correct classification number,total error number,persistent error number, and non-persistent error number between the two groups (P>0.05).After treatment,the total correct number and correct classification number increased significantly in both the two groups (P<0.05),which were 33.23±10.29 and 4.06±2.41 in the observation group versus 27.09±9.82 and 3.21±2.07 in the control group (P<0.05).After treatment,the total number of errors,the number of persistent errors and the number of non-persistent errors decreased significantly in the two groups (P<0.05),which were 14.86±10.27,4.77±3.80,10.34±7.63 in the observation group versus 20.91±9.82,8.35± 4.87 and 12.56±7.08 in the control group (P<0.05).There were no significant differences in CPT1,CPT2,and CPT3 between the two groups before and after treatment (P>0.05).The incidence of adverse reactions in the observation group was 5.0%,significantly lower than 22.5% in the control group (P<0.05).Conclusion The effect of transcranial magnetic stimulation maintenance therapy in patients with recurrent depression is remarkable.It can significantly improve the depressive status of patients,reduce complications,and is safe and reliable,which is worthy of popularization and application in clinic.
作者
李少媚
凌秾喜
林小珍
LI Shao-mei;LING Ji-xi;LIN Xiao-zhen(Functional Department,the Third People's Hospital of Xinhui District of Jiangmen,Jiangmen 529100,Guangdong,CHINA;Intensive Psychiatric Department One,the Third People's Hospital of Xinhui District of Jiangmen,Jiangmen 529100,Guangdong,CHINA;Department of Geriatric Rehabilitation,the Third People's Hospital of Xinhui District of Jiangmen,Jiangmen 529100,Guangdong,CHINA)
出处
《海南医学》
CAS
2019年第8期987-990,共4页
Hainan Medical Journal
关键词
经颅磁刺激
复发性抑郁症
药物
认知功能
不良反应
Transcranial magnetic stimulation
Recurrent depression
Drugs
Cognitive function
Side effects
