卡贝缩宫素联合麦角新碱预防二次剖宫产产后出血的效果观察被引量：14

Observation of the Efficacy of Carbetocin combined with Ergometrine in Preventing Postpartum Hemorrhage of Secondary Cesarean Section in Patients with Scar Uterus

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摘要目的:观察卡贝缩宫素联合麦角新碱预防二次剖宫产产后出血的效果。方法:选取瘢痕子宫产妇200例,根据术中用药情况分成两组,观察组(100例)为卡贝缩宫素联合麦角新碱组,对照组(100例)为单用缩宫素组。结果:两组产妇术后2h出血量比较差异无统计学意义(P>0.05)。观察组术后24h出血量少于对照组,差异有统计学意义(P<0.05)。观察组产后出血发生率为3%,低于对照组的11%,差异有统计学意义(P<0.05)。术中额外用药率观察组为5%,明显低于对照组的22%,差异有统计学意义(P<0.05)。药物的副反应主要为恶心、呕吐,其发生率观察组高于对照组,差异有统计学意义(P<0.05)。结论:卡贝缩宫素联合麦角新碱可降低二次剖宫产产后出血发生率、减少出血量及术中额外使用宫缩剂的概率,预防二次剖宫产产后出血效果确切。 Objective:To observe the effect of carbetocin combined with ergometrine in prevention of postpartum hemorrhage in secondary cesarean section in patients with scar uterus.Methods:A total of 200 cases of pregnant women with cesarean delivery because of scar uterus.In the study,two groups have been divided according to drug use in the operation.The study group was given carbetocin combined with ergometrine(100 cases),while the control group was given oxytocin alone(100 cases).Results:There was no significant difference in 2h postoperative blood loss between the two groups( P <0.05).The postoperative blood loss at 24h was significantly lower in the observation group than in the control group,with statistically significant differences.The rate of postpartum hemorrhage was 3% in the observation group,lower than 11% in the control group,and the difference was statistically significant( P <0.05).The rate of additional drug used in the observation group was 5%,significantly lower than 22% in the control group ,and the difference was statistically significant( P <0.05).The adverse reactions were mainly nausea and vomiting,the incidence was higher in the observation group than in the control group,and the difference was statistically significant( P <0.05).Conclusion:Carbetocin combined with ergometrine in secondary cesarean section can significantly reduce the incidence of postpartum hemorrhage and blood loss,it is more effective to prevent postpartum hemorrhage in secondary cesarean section and to reduce the additional use of uterotonics during cesarean section.

作者杨艳华徐伯兰刘艳娟 YANG Yanhua;XU Bolan;LIU Yanjuan(Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital Binhai Hospital,Tianjin City 300480)

机构地区天津医科大学总医院滨海医院妇产科

出处《医学理论与实践》 2019年第8期1132-1134,共3页 The Journal of Medical Theory and Practice

关键词产后出血缩宫素卡贝缩宫素麦角新碱 Postpartum hemorrhage Oxytocin Carbetocin Ergometrine

分类号 R714.461 [医药卫生—妇产科学]

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参考文献3

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