摘要
目的研究二氧化碳点阵激光联合局部用药治疗甲真菌病的治疗效果。方法将本院的皮肤科就诊的60例甲真菌病患者随机分为观察组与对照组。对照组患者给予外用特比萘芬乳膏进行治疗。观察组给予二氧化碳点阵激光联合外用特比萘芬乳膏进行治疗,对2组患者的治疗效果、治疗满意度以及不良反应进行比较。结果观察组治疗总有效率显著高于对照组(P <0. 05)。男性中,年龄≥50岁,病程≥10年,全甲毁损型,厚度<2 mm,受累甲为非大拇指/趾的病甲分组中,观察组的临床总有效率显著优于对照组(P <0. 05)。女性中,年龄<50岁,病程<10年,非全甲毁损型,厚度> 2 mm,受累甲为大趾以及3种真菌菌种的分组中,观察组的临床有效率均高于对照组,但差异无统计学意义(P> 0. 05)。观察组患者的护理总满意度为70. 00%,显著高于对照组的43. 33%(P <0. 05)。大部分患者在治疗中均出现了不同程度的灼热感,但无患者因为不适而退出本次研究。治疗期间2组患者均无甲下出血、缺损、肝肾功能异常情况出现,尿常规与血常规均正常。结论二氧化碳点阵激光结合特比萘芬乳膏在治疗甲真菌病时能够有效提高治疗效果及满意度。
Objective To study the therapeutic effect of lattice carbon dioxide laser combined with local medication on onychomycosis.Methods Sixty onychomycosis patients in dermatology department of our hospital were selected as study subjects.All patients were randomly divided into observation group and control group according to random number table method.Patients in the control group were treated with lattice carbon dioxide laser,while those in the observation group was treated with lattice carbon dioxide laser combined with external application of luriconazole cream.The therapeutic effect,treatment satisfaction and adverse reactions of the two groups were compared and analyzed.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).According to different grouping,the total clinical effective rate of the observation group was significantly better than that of the male patients with age≥50 years old,diseases course≥10 years,total nail lesion type,thickness<2 mm and involvement nail as non-thumb/toe in the control group(P<0.05),and was also higher in observation group in female patients with age<50 years,course<10 years,partial nail lesion type,thickness greater than 2 mm,involved nail for big toe and three fungal strains of grouping that those in the control group(P>0.05).The total nursing satisfaction of the observation group was 70.00%,which was significantly higher than 43.33%of the control group(P<0.05).Most patients experienced varying degrees of burning sensation in therapy,but none of them quit the study because of discomfort.During the treatment period,there was no abnormal situations occurred such as subthyroid hemorrhage,defect and liver and kidney dysfunction in patients of two groups,and urine and blood routine examinations were normal.Conclusion Lattice carbon dioxide laser combined with luriconazole cream can effectively improve the treatment effect and patients'satisfaction with the treatment in the treatment of onychomycosis.
作者
汪纪红
贾玉琦
陈毅丽
王亚平
WANG Jihong;JIA Yuqi;CHEN Yili;WANFG Yaping(Department of Dermatology,Anting Hospital in Jiading District,Shanghai,201805)
出处
《实用临床医药杂志》
CAS
2019年第7期32-36,共5页
Journal of Clinical Medicine in Practice
基金
上海市市级基金课题(ChiCTR-OOC-140055)
