摘要
近年来耐碳青霉烯类肠杆菌科细菌在新生儿重症监护病房的检出率逐年增加。长时间抗生素使用、人工喂养、中心静脉置管等可能增加新生儿耐碳青霉烯类肠杆菌科细菌败血症(carbapenem-resistant enterobacteriaceae sepsis,CRES)的发生率。CRES的临床表现缺乏特异性,但病情进展迅速,治疗手段有限,易出现休克及多器官功能衰竭,病死率高。血细菌培养是诊断新生儿CRES的金标准。碳青霉烯类抗生素仍是CRES的主要治疗手段,可通过延长输注时间来提高疗效。该文对CRES的临床研究进展进行综述。
Over the years, the isolation rate of carbapenem-resistant enterobacteriaceae have been increasing in the neonatal intensive care unit.The application of carbapenem, formula feeding and central venous device have been considered as the independent predictors for carbapenem-resistant enterobacteriaceae sepsis (CRES). The clinical manifestation of CRES lacks the specificity.CRES is characterized by rapid progression, limited treatment and higher mortality rate.Furthermore, CRES patients have tendency of shock and multiple organ failure.Blood bacterial culture is the golden standard for the diagnosis of CRES.Carbapenem antibiotics are still the main treatment for CRES, and therapeutic effect can be improved by prolonging the infusion time.This article reviews the progress of clinical and basic research on CRE sepsis in recent years.
作者
张莹(综述)
富建华(审校)
Zhang Ying;Fu Jianhua(Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang 110004, China)
出处
《国际儿科学杂志》
2019年第3期166-169,共4页
International Journal of Pediatrics
