摘要
目的观察健脾除湿法联合枸地氯雷他定片治疗小儿湿疹脾虚湿蕴型的临床疗效及对免疫功能的影响。方法选取2016年5月至2017年8月我院收治的湿疹脾虚湿蕴型患儿104例,随机分为对照组和治疗组,各52例。对照组单纯给予枸地氯雷他定片口服治疗,治疗组在对照组治疗方法的基础上给予健脾除湿法治疗。2组均连续治疗4周后,观察临床疗效、治疗前后血清细胞因子水平、中医症状积分及免疫功能指标水平。结果治疗组总有效率为92.31%,显著高于对照组的76.92%,2组比较,差异有统计学意义(P<0.05)。2组治疗前白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)比较,差异均无统计学意义(P>0.05),具有可比性。与同组治疗前比较,治疗后2组IL-2、IFN-γ均显著升高(P<0.05),IL-4显著降低(P<0.05),且治疗组上述指标改善程度均优于对照组,差异有统计学意义(P<0.05)。2组治疗前瘙痒程度、皮疹形态及皮疹面积等症状积分比较,差异均无统计学意义(P>0.05),具有可比性。与同组治疗前比较,治疗后2组各项症状积分均显著降低(P<0.05),且治疗组降幅优于对照组,差异有统计学意义(P<0.05)。2组治疗前CD_4^+、CD_8^+及CD_4^+/CD_8^+比较,差异均无统计学意义(P>0.05),具有可比性。与同组治疗前比较,治疗后2组CD_4^+、CD_4^+/CD_8^+显著升高(P<0.05),CD_8^+显著降低(P<0.05),且治疗组上述指标改善程度均优于对照组,差异有统计学意义(P<0.05)。结论健脾除湿法联合枸地氯雷他定片治疗小儿湿疹脾虚湿蕴型疗效显著,不仅可调节血清细胞因子水平,改善中医症状积分,而且可以显著提高患儿免疫功能。
Objective To observe the clinical efficacy and immunologic function of invigorating spleen to eliminate dampness method combined with desloratadine citrate disodium tablets in the treatment of eczema in children with accumulation of dampness due to spleen-asthenia type.Methods Totally 104 cases of eczema with accumulation of dampness due to spleen-asthenia type admitted to our hospital from May 2016 to August 2017 were randomly divided into control group and treatment group,with 52 cases in each. The control group was given oral desloratadine citrate disodium tablets.On the basis of the control group,the treatment group was given invigorating spleen to eliminate dampness method. After the 2 groups were both consecutively treated for 4 weeks, the clinical efficacy,and serum cytokine levels,TCM symptom scores and the indexes of immunologic function before and after treatment were observed.Results The total effective rate of the treatment group was 92.31%,which was significantly higher than 76.92% of the control group,there was statistically significant difference between the two groups(P<0.05).Before treatment,there were no statistically significant differences in the serum levels of IL-2,IL-4 and IFN-γ between the two groups(P>0.05),and they were comparable.Compared with those of the same groups before treatment,the levels of IL-2 and IFN-γ significantly increased(P<0.05),while IL-4 significantly decreased(P<0.05).Moreover,the extent of improvement of the above-mentioned indexes in the treatment group was all superior to that in the control group,there was statistically significant difference(P<0.05).Before treatment, there were no statistically significant differences in the symptom scores such as itch degree,the appearance and area of the rash between the two groups(P>0.05),and they were comparable.Compared with those of the same groups before treatment,the scores of each symptom in both groups decreased significantly(P<0.05),moreover,the decrease extent of the treatment group was significantly superior to that of the control group,and the difference was statistically significant(P<0.05).Before treatment, there were no statistically significant differences in the levels of CD4^+, CD8^+ and CD4^+/CD8^+ between the two groups(P>0.05), and they were comparable.Compared with those of the same groups before treatment,the levels of CD4^+ and CD4^+/CD8^+ significantly increased in the two groups,while the levels of CD8^+ significantly decreased(P<0.05), moreover,the extent of improvement of the treatment group was superior to that of the control group,and the difference was statistically significant(P<0.05).Conclusion It has a significant effect to combine invigorating spleen to eliminate dampness method with desloratadine citrate disodium tablets in the treatment of eczema in children with accumulation of dampness due to spleen-asthenia type,not only can it regulate the serum cytokine levels,and improve TCM symptom scores,but also it can markedly improve immunologic function of the children patients.
作者
程慧峰
CHENG Huifeng(Department of Pediatrics,the People's Hospital of Changshan County,Changshan,Zhejiang,324200,China)
出处
《中医儿科杂志》
2019年第2期56-60,共5页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
湿疹
小儿
脾虚湿蕴型
健脾除湿法
枸地氯雷他定片
临床观察
eczema
children
accumulation of dampness due to spleen-asthenia type
invigorating spleen to eliminate dampness method
desloratadine citrate disodium tablets
clinical observation
