摘要
目的研究谷氨酰胺对早产儿坏死性小肠结肠炎(NEC)的预防效果。方法选取2016年3月～2018年3月在我院出生的早产儿180例,根据治疗方式不同分为两组,每组均为90例。其中对照组不采用任何预防措施,研究组采用谷氨酰胺进行预防。比较两组早产儿NEC发生率、预后情况及治疗前后的营养情况。结果研究组早产儿NEC发生率1.11%与对照组5.55%,差异无统计学意义(P> 0.05)。治疗前两组早产儿的营养情况比较差异无统计学意义(P> 0.05),治疗后研究组均明显优于对照组,且两组患儿治疗后均相比治疗前出现好转,研究组早产儿不良反应发生率6.67%与对照组33.33%,差异有统计学意义(P <0.05)。出生时两组早产儿平均体重与头围差异无统计学意义(P> 0.05),出院后3个月时,研究组均显著优于对照组,差异有统计学意义(P <0.05)。结论预防使用谷氨酰胺能够有效改善营养情况,患儿体重得到明显增长,保证早产儿能够健康成长,值得应用。
Objective To study the prevention effect of glutamine on premature infants with necrotizing enterocolitis(NEC). Methods One hundred and eighty premature infants who were delivered in our hospital from March 2016 to March 2018 were selected.According to different treatment methods,they were divided into two groups,with 90 cases in each group.The control group was not given any preventive measures while the study group was given glutamine for prevention.The incidence of NEC,prognosis and nutritional status before and after treatment of premature infants were compared between two groups. Results The incidence of NEC of premature infants in the study group(1.11%)and the control group(5.55%)showed no significant difference(P > 0.05).There was no significant difference in nutritional status of premature infants before treatment,P > 0.05.After treatment,the nutritional status in the study group was better than that in the control group.In addition,children in both groups were all improved after treatment compared with before treatment.The incidence of adverse events in the study group was 6.67%,statistically different from that in the control group(33.33%)(P < 0.05).There was no significant difference in average weight and head circumference at birth of premature infants between the two groups(P > 0.05).After discharge from hospital for three months,the average weight and head circumference in the study group were statistically better than those in the control group,and the difference was statistically significant(P < 0.05). Conclusion The preventive use of glutamine can efficiently improve the nutritional status,significantly increase the infants’ birth weight and guarantee healthy growth of premature infants,which is worthy of application.
作者
李正森
车伟坤
梁晶
谢伯威
LI Zhengsen;CHE Weikun;LIANG Jing;XIE Bowei(Department of Neonatology,Gaozhou People’s Hospital,Gaozhou 525200,China)
出处
《中国医药科学》
2019年第8期58-60,64,共4页
China Medicine And Pharmacy
关键词
谷氨酰胺
早产儿
坏死性小肠结肠炎
预防
Glutamine
Premature infants
Necrotizing enterocolitis
Prevention
