摘要
目的了解拉萨市藏族成年人尿碘水平的分布以及与甲状腺功能的关系。方法通过对拉萨及周边农村藏族成年人进行多阶段分层整群随机抽样,测定其日常食盐、饮水碘含量及尿碘、甲状腺功能水平[包括TSH、抗甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)];再按照尿碘水平分为碘摄入不足组(尿碘<100 μg/L)、足量组(尿碘100~199 μg/L)、超足量组(尿碘200~299 μg/L)及过量组(尿碘≥300 μg/L),比较各组间甲状腺功能水平差异。结果本研究共纳入受试者2 235例,尿碘整体水平呈偏态分布,其中位数(四分位数间距)为154(99,229)μg/L。碘摄入不足组的人群比为25.7%,适量组为41.5%,超足量组为21.3%,过量组为11.5%。男性尿碘为152(95,219)μg/L,女性尿碘为155(100,232)μg/L,差异无统计学意义(P>0.05);城市人群尿碘水平高于农村人群[157(101,232)对140(92,200)μg/L,P<0.05];青年组、中年组及老年组尿碘水平分别为175(116,256)、136(91,200)和116(68,164)μg/L,随着年龄的增长,尿碘水平逐渐降低(P<0.05)。拉萨市藏族成年人平均食盐碘含量为23.16 mg/kg,平均饮水碘含量为4.33 μg/L。不同碘摄入组TSH水平差异无统计学意义(P>0.05),各组TPOAb和TGAb水平差异虽有统计学意义(均P<0.05),但无明确临床意义。结论拉萨市藏族成年人低碘和高碘人群超过50%,食盐碘含量符合国家标准,而饮水碘含量低于国家标准,尿碘与甲状腺功能未见明确关系。
bjective To investigate the distribution of urinary iodine level and its relationship with thyroid function in Tibetan adults in Lhasa. Methods Tibetan residents living in Lhasa and its surrounding countryside were recruited by the method of multistage randomized cluster sampling. Their salt iodine, drinking water iodine, urinary iodine, and thyroid function levels were detected. According to the urinary iodine level, these subjects were divided into the iodine deficiency group (urinary iodine<100 μg/L), the iodine enough group (urine iodine 100-199 μg/L), the iodine adequate group (urine iodine 200-299 μg/L) and the iodine excessive group (urine iodine≥300 μg/L). The differences in thyroid function among various groups were compared. Results A total of 2 235 subjects were included in the study. The overall level of urinary iodine was in skewed distribution, with a median (upper and lower quartiles) of 154 (99, 229)μg/L. The proportion of subjects with insufficient iodine intake was 25.7%, while those of the enough, adequate, and excessive groups were 41.5%, 21.3%, and 11.5%, respectively. There was no significant difference in urine iodine level between males and females [152(95, 219)μg/L vs 155(100, 232)μg/L P>0.05]. The urinary iodine levels in residents of urban were higher than those in rural residents [157(101, 232)μg/L vs 140(92, 200)μg/L, P<0.05]. The urinary iodine levels in the young, middle-aged, and elderly groups were 175 (116, 256), 136 (91, 200), and 116 (68, 164)μg/L respectively, showing a gradual decrease in urine iodine level with aging (P<0.05). The average salt iodine content of Tibetan adults in Lhasa was 23.16 mg/kg, and that in drinking water was 4.33 μg/L. There were no significant differences in TSH levels among various iodine intake groups(P>0.05). The levels of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) were gradually decreased with the increase of urinary iodine level (P<0.05). Conclusion More than 50% of Tibetans are at the status of low iodine and high iodine intakes in Lhasa. Although the salt iodine content meets national standards, the drinking water iodine content is lower than that standard.
作者
宁蓬
罗樱樱
任倩
孟树优
宋嘉
吕雪梅
阿米娜
巴桑普赤
杨丽辉
Ning Peng;Luo Yingying;Ren Qian;Meng Shuyou;Song Jia;Lyu Xuemei;A Mina;Ba Sangpuchi;Yang Lihui(Tibet University Medical College & Department of Endocrinology,People′s Hospital of Tibet Autonomous Region,Lhasa 850000,China;Department of Endocrinology,People′s Hospital of Peking University,Beijing 100032,China;Department of Endocrinology,People′s Hospital of Tibet Autonomous Region,Lhasa 850000,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2019年第4期314-318,共5页
Chinese Journal of Endocrinology and Metabolism
基金
TIDE项目赞助课题,公益性行业科研专项(201402005)
中华医学会临床医学科研专项资金资助项目(15010010589).
关键词
拉萨
藏族
尿碘
甲状腺功能
Lhasa
Tibetan
Urinary iodine
Thyroid function
