摘要
目的探讨扶正化瘀胶囊联合异甘草酸镁治疗失代偿期肝硬化临床疗效及对肝功能、肝纤维化指标的影响。方法选取2015年1月～2017年6月于唐山市传染病医院和华北理工大学附属医院住院的失代偿期肝硬化患者120例,按照随机数字表法分为对照组和病例组,每组各60例。对照组给予常规保肝治疗+异甘草酸镁治疗,病例组给予常规保肝治疗+异甘草酸镁+扶正化瘀治疗。两组均治疗2周。观察两组患者的临床疗效及治疗前后肝纤维化指标及肝功能变化。结果病例组临床有效率为95.00%,较对照组的81.67%显著升高,差异有统计学意义(P <0.05)。治疗后,两组肝功能、肝纤维化指标总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、层黏连蛋白(LN)、Ⅳ型胶原(CIV)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)水平降低,白蛋白(ALB)、胆碱酯酶(CHE)水平升高,差异有统计学意义(P <0.05)。治疗后,与对照组比较,病例组TBIL、ALT、AST、LN、CIV、HA、PCⅢ水平降低,ALB、CHE水平升高,差异有统计学意义(P <0.05)。结论扶正化瘀联合异甘草酸镁治疗失代偿期肝硬化患者效果显著,能够明显改善肝功能和肝纤维化程度,具有协同作用。
Objective To investigate the effect of Fuzheng Huayu Capsules combined with Magnesium Isoglycerate on liver function and hepatic fibrosis in patients with decompensated cirrhosis. Methods A total of 120 cases with decompensated cirrhosis hospitalized in Tangshan City Hospital for Infectious Diseases and Affiliated Hospital of North China University of Technology from January 2015 to June 2017 were selected. According to random number table method, the patients were divided into control group and case group with 60 cases in each group. The control group was given conventional liver protection plus Magnesium Isoglycyrrhizate, and the case group was given conventional liver protection plus Magnesium Isoxalate and Fuzheng Huayu Capsules. Both groups were treated for 2 weeks. Clinical efficacy, liver fibrosis index and liver function of the two groups before and after treatment were observed. Results The effective rate was 95.00% in the case group, which was significantly higher than 81.67% in the control group, the difference was statistically significant (P < 0.05). After treatment, compared with before treatment, The levels of total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), layer adhesion protein (LN), type Ⅳ collagen (CIV), hyaluronic acid (HA), and before collagen Ⅲ type (PCⅢ) were decreased, while the levels of albumin (ALB) and cholinesterase (CHE) were increased the difference was statistically significant (P < 0.05). After treatment, liver function and liver fibrosis index TBIL, ALT, AST, LN, CIV, HA, PCⅢ levels decreased, levels of ALB and CHE increased in the two groups, the differences were statistically significant (P < 0.05). After treatment, compared with the control group, levels of TBIL, ALT, AST, LN, CIV, HA, PCⅢ decreased, while the levels of ALB and CHE increased in the case group, the differences were statistically significant (P < 0.05). Conclusion The effect of Fuzheng Huayu Capsules combined with Magnesium Isoserate in the treatment of chronic liver cirrhosis is significant. It can obviously improve the liver function and the degree of liver fibrosis, and it has a synergistic effect.
作者
李晓永
张国顺
LI Xiaoyong;ZHANG Guoshun(Department of Hepatology, Tangshan City Hospital for Infectious Diseases, Hebei Province, Tangshan 063000, China;Department of Gastroenterology, Affiliated Hospital of North China University of Science and Technology, Hebei Province, Tangshan 063000, China)
出处
《中国医药导报》
CAS
2019年第11期138-141,共4页
China Medical Herald
基金
中国肝炎防治基金会资助项目(TQGB20170015)
河北省医学科学研究重点课题计划项目(20170933)
关键词
扶正化瘀
异甘草酸镁
失代偿期肝硬化
肝功能
肝纤维化
Fuzheng Huayu
Magnesium Isoglycyrrhizinate
Decompensated cirrhosis
Liver function
Liver fibrosis
