摘要
目的分析生长抑素、加贝酯联合乌司他丁治疗急性胰腺炎的临床疗效。方法本研究选择2017年1月～2018年1月在我院住院治疗的急性胰腺炎患者70例作为研究对象,将全部患者随机分为观察组和对照组,每组35例,两组患者均予禁食、胃肠减压、积极补液、调节水电解质紊乱、抗生素、抑制胃酸、奥曲肽抑制胰酶分泌等治疗。对照组予生长抑素、加贝酯治疗,观察组同时联合乌司他丁治疗,治疗后比较两组的临床疗效、上腹压痛缓解时间、血尿淀粉酶恢复时间及并发症发生率。结果治疗后,观察组的总有效率达94.28%,显著高于对照组的71.43%,两组临床疗效对比,差异具有统计学意义(P<0.05)。观察组患者的上腹压痛缓解时间、血尿淀粉酶恢复时间显著短于对照组,观察组患者的并发症发生率显著低于对照组(5.71%vs 28.57%),两组对比,差异具有统计学意义(P<0.05)。其中观察组32例患者中发生多器官功能衰竭1例,假性囊肿1例,对照组发生胰周感染3例,多器官功能衰竭3例,假性囊肿4例。结论生长抑素、加贝酯联合乌司他丁治疗急性胰腺炎疗效确切,可以显著改善临床症状,且并发症少,值得临床广泛推广和应用。
Objective To analyze the clinical efficacy of somatostatin,gabexate combined with ulinastatin in the treatment of acute pancreatitis.Methods A total of 70 patients with acute pancreatitis in our hospital from January 2017 to January 2018 were enrolled.All patients were randomly divided into observation group and control group,with 35 patients in each group.Both groups were treated with fasting,gastrointestinal decompression,active fluid replacement,regulation of water and electrolyte disorders,antibiotics,inhibition of gastric acid,octreotide inhibition of pancreatic enzyme secretion,etc.The control group was treated with somatostatin and gabexate.The observation group was treated with ulinastatin.After treatment,the clinical efficacy,the time of relief of upper abdominal tenderness,the recovery time of hematuria and amylase and the incidence of complications between two groups were compared.Results After treatment,the total effective rate of the observation group was 94.28%,which was significantly higher than the total effective rate of the control group(71.43%).The clinical efficacy between the two groups was statistically significant(P<0.05).The upper abdominal tenderness relief time and the recovery time of hematuria and amylase in the observation group were significantly shorter than those of the control group.The incidence of complications in the observation group was significantly lower than that of the control group(5.71%vs 28.57%).The difference between two groups was significant(P<0.05).Among the 32 patients in the observation group,1 case had multiple organ failure,1 case had pseudocyst.In the control group 3 cases had peripancreatic infection,3 cases had multiple organ failure,and 4 cases had pseudocyst.Conclusion Somatostatin,gabexate combined with ulinastatin are effective in the treatment of acute pancreatitis,which can significantly improve clinical symptoms,have fewer complications and are worthy of clinical promotion and application.
作者
钟江鹏
ZHONG Jiangpeng(Department of Gastroenterology,Changle People's Hospital in Shandong Province,Changle 262400,China)
出处
《中国现代医生》
2019年第10期109-111,共3页
China Modern Doctor
关键词
急性胰腺炎
生长抑素
乳腺癌
加贝酯
Acute pancreatitis
Somatostatin
Breast cancer
Gabexate
