摘要
目的:研究超声Tei指数与肿瘤患者胸部放疗后心脏损伤的相关性。方法:选择在我院接受胸部放疗的恶性肿瘤患者作为观察组,同期体检的健康志愿者作为对照组。观察组分别在放疗前和放疗后进行心脏超声检查并计算Tei指数,采集血清并测定心脏损伤标志物、炎症细胞因子、氧化应激介质;对照组体检时进行心脏超声检查,并计算Tei指数,采集血清并测定心脏损伤标志物、炎症细胞因子、氧化应激介质。结果:观察组放疗后的左心Tei指数、右心Tei指数及血清磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、干扰素诱导蛋白-10(IP-10)、白细胞介素-6(IL-6)、IL-10、转化生长因子-β1(TGF-β1)、8-羟基脱氧鸟苷酸(8-OhdG)的含量均明显高于放疗前及对照组,血清总抗氧化力(T-AOC)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)含量均明显低于放疗前及对照组;Tei指数与血清CK、CK-MB、cTnI、IP-10、IL-6、IL-10、TGF-β1、8-OhdG含量呈正相关,与血清T-AOC、SOD、GPx含量呈负相关。结论:超声Tei指数对肿瘤患者胸部放疗后的心脏损伤具有评估价值。
Objective:To study the correlation between ultrasound Tei index and cardiac injury in cancer patients after thoracic radiotherapy.Methods:The patients with malignant tumor who received thoracic radiotherapy in our hospital between February 2015 and March 2018 were selected as the observation group,and healthy volunteers who underwent physical examination during the same period were selected as the control group.Observation group underwent cardiac ultrasonography before and after radiotherapy to calculate Tei indexes and serum was collected to determine cardiac injury markers,inflammatory cytokines and oxidative stress mediators;control group underwent cardiac ultrasonography during the physical examination to calculate Tei indexes and serum was collected to determine cardiac injury markers,inflammatory cytokines and oxidative stress mediators.Results:Left cardiac Tei index,right cardiac Tei index as well as serum creatine phosphokinase(CK),creatine phosphokinase isoenzyme(CK-MB),troponin I(cTnI),interferon induced protein-10(IP-10),interleukin-6(IL-6),IL-10,transforming growth factor-β1(TGF-β1)and 8-hydroxy-2-deoxyguanosine(8-OhdG)contents of the observation group after radiotherapy were significantly higher than those before radiotherapy and those of the control group while serum total antioxidant capacity(T-AOC),superoxide dismutase(SOD)and glutathione peroxidase(GPx)contents were significantly lower than those before radiotherapy and those of the control group;Tei indexes were positively correlated with serum CK,CK-MB,cTnI, IP-10,IL-6,IL-10,TGF-β1and 8-OhdG contents,and negatively correlated with serum T-AOC,SOD,and GPx contents. Conclusion:Ultrasound Tei index is valuable in evaluating the cardiac injury in cancer patients after thoracic radiotherapy.
作者
卫云峰
郭道宁
丁倩
张羽
朱一平
WEI Yun-feng;GUO Dao-ning;DING Qian;ZHANG Yu;ZHU Yi-ping(Department of Ultrasound Medicine,Mianyang Central Hospital in Sichuan Province,Mianyang,Sichuan Province,621000, China;Department of Oncology,Mianyang Central Hospital in Sichuan Province,Mianyang,Sichuan Province,621000,China)
出处
《海南医学院学报》
CAS
2019年第9期708-711,716,共5页
Journal of Hainan Medical University
基金
2017年四川省医学科研青年创新课题立项(Q17044)~~
关键词
放疗
心脏损伤
TEI指数
炎症细胞因子
氧化应激
Radiotherapy
Cardiac injury
Tei index
Inflammatory cytokine
Oxidative stress
