摘要
目的探究小牛血去蛋白提取物眼用凝胶对干眼症患者泪膜稳定性及炎症因子水平的影响。方法选取我院2016年1月至2018年6月收治的90例干眼症患者作为研究对象,根据治疗顺序数字尾数单双号将其分为对照组和观察组,各45例。对照组采用羟糖甘滴眼液治疗,观察组采用小牛血去蛋白提取物眼用凝胶治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组BUT、FL、SⅠt无明显差异(P>0.05);治疗后,两组BUT、FL、SⅠt均明显改善,且观察组优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的IL-1β、TNF-α水平无明显差异(P>0.05);治疗后,两组IL-1β、TNF-α水平均降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。结论小牛血去蛋白提取物眼用凝胶治疗干眼症效果显著,不仅可以提高泪膜稳定性,还可以降低炎症因子水平,值得临床广泛应用。
Objective To investigate the effect of deproteinized calfblood extract eye gel on tear film stability and the levels of inflammatory factors in xeroma patients.Methods A total of 90 xeroma patients admitted in our hospital from January 2016 to June 2018 were selected as the research objects and divided into control group and observation group according to the treatment mantissa odd and even number,with 45 cases in each group.The control group was treated with hydroxyglycogen eye drops,and the observation group was treated with deproteinized calfblood extract eye gel.The therapeutic effects of two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in BUT,FL and SⅠt between the two groups (P>0.05);after treatment,BUT,FL and SⅠt in the two groups significantly improved,and those in the observation group were better than the control group (P<0.05).There were no significant differences in the levels of IL-1β and TNF-α between the two groups before treatment (P>0.05);after treatment,the levels of IL-1β and TNF-α in the two groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).Conclusion Deproteinized calfblood extract eye gel in the treatment of xeroma has a significant effect.It can not only improve the stability tear film,but also reduce the level of inflammatory factors,which is worthy of widely clinical application.
作者
高路
郑树锋
GAO Lu;ZHENG Shu-feng(Yan'an Hospital of TCM,Yan'an 716000;Traditional Chinese Hospital of Yulin,Yulin 719000,China)
出处
《临床医学研究与实践》
2019年第13期115-117,共3页
Clinical Research and Practice
