摘要
为了探讨2型糖尿病(T2D)患者外周血血清胰岛素样生长因子1(IGF-1)水平与糖脂代谢水平的关系,分析T2D患者血清IGF-1的相关影响因素。通过选取2010年5月～2012年1月就诊于内蒙古医科大学附属医院、内蒙古中医院内分泌科的179例T2D住院患者作为病例组(T2D组),另选取30例内蒙古医科大学体检中心正常健康体检者作为对照组(CK组)。采集研究对象空腹外周血,应用ELISA法检测血清IGF-1水平;检测T2D患者生化血脂指标和糖代谢指标水平,利用调查问卷收集研究对象的一般资料、行为习惯和体格检查,计算体质指数(BMI)、胰岛素抵抗指数(HOMA-IR)及胰岛素敏感性指数(HOMA-IS)。将T2D组患者IGF-1水平按照第25、75百分位数分为低IGF-1水平组(B组)、中IGF-1水平组(C组)和高IGF-1水平组(D组),CK组为对照组(A组)进行比较的方法,研究IGF-1水平与以上指标的相关性。结果表明:T2D组与CK组IGF-1水平差异显著(P <0. 01)。A组、B组、C组和D组比较中,年龄、性别、吸烟史、饮酒史、运动情况及BMI差异显著(P <0. 05);空腹血糖(FPG)、餐后2 h血糖(2PPBS)和糖化血红蛋白(Hb Alc)差异有统计学意义;三组载脂蛋白A(Apoal)均与对照组差异显著,D组的高密度脂蛋白胆固醇(HDL-C)与A组相比差异有统计学意义。相关性分析显示,血清IGF-1水平与运动情况(Spearman铁相关系数为0. 23,P=0. 001)存在关联。以IGF-1浓度为因变量的多因素Logistic回归分析中,血清IGF-1水平与胰岛素敏感性、年龄、BMI和Apoal、FPG、空腹胰岛素(FINS)及Hb Alc的交互作用正相关,与HDL-C负相关。可见胰岛素敏感性、年龄、BMI及Apoal、FPG、FINS与Hb Alc的交互作用可能为IGF-1水平的独立危险因素,HDL-C可能为独立保护因素。
To investigate the relationship between serum insulin-like growth factor 1(IGF-1) levels and glucose and lipid metabolism levels in patients with type 2 diabetes(T2D),the factors affecting serum IGF-1 in T2D patients were analyzed. 179 T2D hospitalized patients in the Department of Endocrinology,Inner Mongolia Medical University Hospital and Inner Mongolia Traditional Chinese Medicine Hospital from May 2010 to January 2012 were selected as the case group(T2D group),and 30 cases of internal health examinations of the Inner Mongolia Medical University Medical Center were selected as control group(CK group). The fasting peripheral blood of the study subjects were collected. The serum IGF-1 level was detected by ELISA. The biochemical lipid index and glucose metabolism index of T2D patients were detected. The general data,behavioral habits and physical examination of the subjects were collected by questionnaire. The body mass index(BMI),insulin resistance index(HOMA-IR)and insulin sensitivity index(HOMA-IS) were calculated. IGF-1 levels in the T2D group were divided into low IGF-1 level group(group B),middle IGF-1 level group(group C) and high IGF-1 level group(group D) according to the 25 th and 75 th percentile. The CK group was compared with the control group(group A) to study the correlation between IGF-1 levels and the above indicators. The results show that the levels of IGF-1 in the T2D group and the CK group significantly different(P < 0. 01). Age,gender,smoking history,drinking history,exercise status,and BMI are significantly different in group A,group B,group C,and group D(P < 0. 05). About fasting blood glucose(FPG),postprandial 2-hour blood glucose(2 PPBS) and glycated hemoglobin(HbAlc),there are significant difference between the three groups. The apolipoprotein A(Apoal) is significantly different from the control group. The difference of high-density lipoprotein cholesterol(HDL-C) in group D is statistically different from that in group A. Correlation analysis shows that serum IGF-1 levels are associated with exercise(Spearman rank correlation coefficient is 0. 23,P = 0. 001). In the multivariate logistic regression analysis with IGF-1 concentration as the dependent variable,serum IGF-1 levels are positively correlated with insulin sensitivity,age,BMI and the interaction of Apoal,FPG,fasting in sulin(FINS) and HbAlc,and negatively correlated with HDL-C. It can be seen that insulin sensitivity,age,BMI and the interaction of Apoal,FPG,FINS and HbAlc may be independent risk factors for IGF-1 levels,and HDL-C may be an independent protective factor.
作者
庞慧
高玉敏
赵燕平
张东雪
崔萌
贾敏
赵灵燕
PANG Hui;GAO Yu-min;ZHAO Yan-ping;ZHANG Dong-xue;CUI Meng;JIA Min;ZHAO Ling-yan(Institute of Public Health, Laboratory of Molecular Epidemiology of Chronic Diseases, Hohhot 010110, China;Institute of Public Health, Inner Mongolia Medical University,, Hohhot 010110, China;Institute of Public Health , Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010110, China)
出处
《科学技术与工程》
北大核心
2019年第12期90-96,共7页
Science Technology and Engineering
基金
国家自然科学基金(81660564)
内蒙古自然科学基金(2018MS08014)
内蒙古医科大学慢性病分子流行病学创新团队项目(YKD2017KJCXTD015)资助
