摘要
目的:探讨喹硫平联合丙戊酸镁对双相情感障碍患者狂躁、抑郁症状及血清总胆红素、白蛋白水平的影响。方法:选择2016年4月至2018年10月我院收治的双相情感障碍患者78例,按随机双盲法分为两组,各39例。对照组给予丙戊酸镁口服,观察组在此基础上给予喹硫平口服治疗。比较两组患者临床疗效、躁狂量表(BRMS)评分、汉密尔顿抑郁量表(HAMD)评分、血清总胆红素(TBIL)、白蛋白(Alb)及不良反应。结果:治疗2周后,观察组总有效率(92. 31%)高于对照组(79. 49%),差异有统计学意义(P <0. 05);治疗2周后,两组BRMS、HAMD评分降低,TBIL、Alb水平升高,且观察组BRMS、HAMD低于对照组,TBIL、Alb高于对照组,差异有统计学意义(P <0. 05);治疗2周内,观察组不良反应发生率(15. 39%)略高于对照组(10. 26%),差异无统计学意义(P> 0. 05)。结论:喹硫平联合丙戊酸镁治疗双相情感障碍疗效确切,可改善患者狂躁、抑郁症状,提高血清TBIL、Alb水平,改善抗氧化能力。
Objective:To investigate the effect of quetiapine combined with magnesium valproate on mania,depression,serum total bilirubin and albumin in patients with bipolar affective disorder.Methods:78 patients with bipolar affective disorder admitted in the hospital from April 2016 to October 2018 were selected,and they were divided into two groups by randomized double blind method,with 39 cases in each group.Control group orally took magnesium valproate,while observation group was treated with oral quetiapine based on control group.The clinical efficacy,Bech-Rafaelsen Mania Rating Scale(BRMS),Hamilton Depression Rating Scale(HAMD),serum total bilirubin(TBIL),albumin(Alb),adverse reactions were compared between the two groups.Results:After treatment for 2 weeks,the total effective rate of observation group(92.31%)was higher than control group(79.49%)(P<0.05);After treatment for 2 weeks,the scores of BRMS and HAMD in the two groups decreased,the levels of TBIL and Alb in the two groups increased,the BRMS and HAMD of observation group were lower than those of control group,while the TBIL and Alb in observation group were higher than those in control group(P<0.05);During 2 weeks of treatment,the incidence of adverse reactions in observation group(15.39%)was slightly higher than control group(10.26%),but there was no statistical difference(P>0.05).Conclusion:Quetiapine combined with magnesium valproate in treatment of bipolar affective disorder is effective,it can improve mania and depression of patients,increase the levels of serum TBIL and Alb,and enhance antioxidant ability.
作者
张飞龙
ZHANG Fei-long(Luoyang Fifth People's Hospital,Henan Luoyang 471000,China)
出处
《中国药物评价》
2019年第2期144-146,共3页
Chinese Journal of Drug Evaluation
关键词
双相情感障碍
喹硫平
丙戊酸镁
临床疗效
血清总胆红素
白蛋白
Bipolar affective disorder
Quetiapine
Magnesium valproate
Clinical efficacy
Serum total bilirubin
Albumin
