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体外药敏试验指导胃癌个体化新辅助化疗的临床意义

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摘要 目的探讨肿瘤体外药敏试验在进展期胃癌个体化新辅助化疗中的应用价值。方法回顾性分析30例SOX方案新辅助化疗的进展期胃癌患者和30例肿瘤体外药敏试验指导新辅助化疗方案患者的临床资料。分析两组新辅助化疗次数、不良反应情况、影像学消退率、围术期各项指标及病理学缓解率的差异。结果两组不良反应情况、术中清扫淋巴结个数及术后住院时间差异均无统计学意义(均> 0.05);两组新辅助化疗次数、手术时间、术中出血量、影像学缓解率、手术根治率及肿瘤病理缓解率差异均有统计学意义(均<0.05)。结论肿瘤体外药敏试验在指导进展期胃癌新辅助化疗领域安全、有效,能减少新辅助化疗次数、缩小肿瘤体积、提高R0切除率、改善肿瘤病理学缓解有效率,具有一定的临床意义。
出处 《现代实用医学》 2019年第4期459-462,共4页 Modern Practical Medicine
基金 浙江省医药卫生科技计划项目(2015KYB345) 宁波市医学重点学科项目(2016-55) 宁波市自然科学基金(2015A610230)
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