摘要
目的:研究彩色能量多普勒超声阻力指数与宫颈癌患者血管内皮生长因子(VEGF)、微血管密度(MVD)以及临床病理特征的关系。方法:以2015年2月-2018年2月我院收治的宫颈癌患者50例为研究对象,记为宫颈癌组。另取同期于我院接受治疗的宫颈上皮内瘤变患者50例记为宫颈上皮内瘤变组,取同期于我院体检的健康志愿者50例记为对照组。采用经阴道彩色能量多普勒超声检测三组受试者阻力指数,采用免疫组织化学法检测三组受试者VEGF表达以及MVD值。分别比较三组受试者阻力指数、VEGF表达及MVD值,并分析宫颈癌患者阻力指数与临床病理特征的关系,同时采用Spearman相关性分析宫颈癌患者阻力指数与VEGF、MVD的相关性。结果:宫颈癌组阻力指数低于宫颈上皮内瘤变组和对照组,且宫颈上皮内瘤变组低于对照组(P<0.05);而宫颈癌组VEGF表达与MVD值高于宫颈上皮内瘤变组和对照组,且宫颈上皮内瘤变组高于对照组(P<0.05)。病灶直径<40 mm、临床分期Ⅰ-Ⅱ期、中高分化、无淋巴结转移宫颈癌患者阻力指数均高于病灶直径≥40 mm、临床分期Ⅲ-Ⅳ期、低分化、有淋巴结转移宫颈癌患者(P<0.05),而阻力指数与宫颈前后径、组织学类型无关(P>0.05)。经Spearman相关性分析可得:宫颈癌患者阻力指数与VEGF以及MVD均呈负相关(P<0.05)。结论:彩色能量多普勒超声可有效反映宫颈病变形态结构特征、血管生成状况以及浸润情况,临床工作中可联合彩色能量多普勒超声与VEGF、MVD的测定,有助于判断宫颈癌患者病情严重程度,为临床治疗方案的制定以及预后评估提供参考依据。
Objective:To study the relationship between resistance index of color power Doppler ultrasound and vascular endothelial growth factor(VEGF),microvascular density(MVD),clinicopathological features in patients with cervical cancer.Methods:50 patients with cervical cancer who were treated in our hospital from February 2015 to February 2018 selected as research object and recorded as a cervical cancer group.Another 50 patients with cervical intraepithelial neoplasia who were treated in our hospital in the same period were recorded as cervical intraepithelial neoplasia group,and 50 healthy volunteers who were received physical examination in our hospital in the same period were recorded as control group.Transvaginal color power Doppler ultrasound was used to detect the resistance index of the three groups.Immunohistochemistry was used to detect the expression of VEGF and MVD value in three groups.The resistance index,VEGF expression and MVD value of the three groups were compared.The relationship between resistance index and clinicopathological features of patients with cervical cancer was analyzed.At the same time,Spearman correlation was used to analyze the correlation between resistance index and VEGF,MVD in patients with cervical cancer.Results:The resistance index of the cervical cancer group was lower than that of the cervical intraepithelial neoplasia group and the control group,and the cervical intraepithelial neoplasia group was lower than that of the control group,the expression of VEGF and MVD value in cervical cancer group were higher than those in cervical intraepithelial neoplasia group and control group,and the cervical intraepithelial neoplasia group were higher than those in control group(P<0.05).The resistance index in patients with lesion diameter<40 mm,clinical stage with I-II stages,middle and high differentiation,no lymph node metastasis were higher than that of the lesion diameter≥40 mm,clinical stage with III-IV stages,low differentiation,lymph node metastasis(P<0.05),and the resistance index was not related to the anteroposterior diameter of the cervix and histological type(P>0.05).Spearman correlation analysis showed that the resistance index of patients with cervical cancer was negatively correlated with VEGF and MVD(P<0.05).Conclusion:Color power Doppler ultrasound can effectively reflect the morphological features,angiogenesis and infiltration of cervical lesions.In clinical work,it is possible combined with color power Doppler ultrasound and VEGF,MVD to effectively judge the severity of patients with cervical cancer,and it can provide a basis for formulating clinical treatment protocols and evaluating prognosis.
作者
秦凌云
蒋呈欣
蒙正浩
张亚丽
秦格秀
QIN Ling-yun;JIANG Cheng-xin;MENG Zheng-hao;ZHANG Ya-li;QINGe-xiu(Department of Medical Imaging,181st Hospital of People's Liberation Army,Guilin,Guangxi,541002,China)
出处
《现代生物医学进展》
CAS
2019年第6期1126-1129,1155,共5页
Progress in Modern Biomedicine
基金
广西壮族自治区自然科学基金项目(2013GX25208)
关键词
宫颈癌
彩色能量多普勒超声
阻力指数
临床病理特征
血管内皮生长因子
微血管密度
Cervical cancer
Color power Doppler ultrasound
Resistance index
Clinicopathological features
Vascular endothelial growth factor
Microvascular density
