摘要
烟碱是存在于烟草植物中的主要生物碱,是代表性的乙酰胆碱激动剂类药物,对中枢神经系统以及乙酰胆碱受体均有一定作用。文章针对烟碱对烟碱抗阿尔茨海默病的作用机制进行综述,并对阿尔茨海默病的治疗作用展开讨论。如:调节胆碱能、减轻氧化应激、抑制Aβ生成及聚合以及神经保护作用。为抗阿尔茨海默病的药物筛选提供了一条极具潜力的研发途径。
Nicotine,the main alkaloid found in tobacco plants,which is a representative agonist of acetylcholine,has some effect on the central nervous system and acetylcholine receptors.In this article,the mechanism of nicotine resistance to Alzheimer’s disease was summarized and the therapeutic effect of nicotine on Alzheimer’s disease was also discussed,such as regulating cholinergic,reducing oxidative stress,inhibiting Aβproduction and aggregation,and neuroprotective effects.It provides a promising approach to drug screening for Alzheimer’s disease.
作者
程生博
帖金鑫
李萌
马林
CHENG Sheng-bo;TIE Jin-xin;LI Meng;MA Lin(Zhengzhou University of Light Industry,Key Laboratory of biotechnology in tobacco,Zhengzhou,Henan,450001,China;Technology Center,China Tobacco Zhejiang Industrial Co.,Ltd.,Hangzhou,Zhejiang,310024,China)
出处
《现代生物医学进展》
CAS
2019年第5期975-978,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(20976169)
关键词
烟碱
阿尔茨海默病
氧化应激
神经保护
Nicotine
Alzheimer's disease
Oxidative stress
Neuroprotective
