摘要
目的:观察复方龙月利胶囊对大鼠的长期毒性反应。方法:将SPF级SD大鼠80只随机分为4组,每组20只。复方龙脷胶囊高、中、低(19.6、9.8、4.9 g/kg)3个剂量组相当于人用临床剂量(0.14 g/kg)的140、70、35倍,空白对照组给予同体积蒸馏水,连续灌胃30天,停药后观察14天。每日观察大鼠的一般状况,检测给药后及停药观察期大鼠的血液学指标、血液生化学指标、脏器系数,并做组织病理学检查。结果:给药30天及停药观察14天未见药物引起的毒性反应及延迟性毒性反应。结论:复方龙月利胶囊长期用药对大鼠无明显毒性,按临床拟用剂量服用应是安全的。
Objective: To observe long-term toxicity of compound LongLi capsules in rats. Methods: Eighty rats were randomized into four groups, 20 rats each group. High, moderate and low dose groups (19.6, 9.8 and 4.9 g/kg) of compound LongLi capsules equal to 140, 70 and 35 times of clinical dose (0.14 g/kg), blank control group were given distilled water of the same volume. The rats were drenched for 30 consecutive days and observed for 14 days after drug withdrawal. To observe general conditions of the rats each day, to detect hematological indexes, blood chemical indexes and organ coefficient of the rats after medicating and during the observation period after drug withdrawal, and perform histopathological examination. Results: No drug-induced toxic reaction or delayed toxic reaction has been found after medicating for 30 days and within 14 days after drug withdrawal. Conclusion: Long-termapplication of compound LongLi capsules shows no obvious toxicity in rats, it should be safe to administer in clinical dose.
作者
陈晓军
李燕婧
谭建宁
曾宪彪
韦宝伟
韦桂宁
陈敬民
覃良
吕纪华
CHEN Xiaojun;LI Yanjing;TAN Jianning;ZENG Xianbiao;WEI Baowei;WEI Guining;CHEN Jingmin;QIN Liang;LYU Jihua(Guangxi Institute of Chinese Medicine & Pharmaceutical Sciences, Nanning 530022, China;Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards;Guangxi Hospital of Traditional Chinese Medicine)
出处
《西部中医药》
2019年第3期21-25,共5页
Western Journal of Traditional Chinese Medicine
基金
广西科学研究与技术开发计划项目(编号桂科攻11107009-2-6)
关键词
复方龙月利胶囊
大鼠
长期毒性
compound LongLi capsules
rats
long-termtoxicity
