摘要
自噬在急性白血病发生、发展中具有重要的双重作用:一方面可以诱导白血病细胞的凋亡,抑制疾病发展,另一方面可以对白血病细胞产生保护作用而维持细胞生存,以及抵抗化疗药物诱导的凋亡。目前已有研究发现通过调控自噬可增强急性白血病细胞的药物敏感性,促进白血病细胞死亡。因此,通过调控自噬有望为难治复发急性白血病找到更为有效的治疗措施。文章对近年来自噬与急性白血病治疗相关研究进展进行综述。
Autophagy plays an important dual role in the occurrence and development of acute leukemia,inducing the apoptosis of leukemia cells to suppress the development of acute leukemia,and protecting the leukemia cells to sustain the survival and to resist the apoptosis induced by chemotherapy drugs.Some studies have showed that the drug sensitivity of acute leukemia cells can be improved by regulating autophagy to induce the apoptosis of leukemia cells,and thus,regulating autophagy is expected to be an effective therapeutic strategy of refractory/relapsed acute leukemia.This article reviews the recent progress of autophagy and acute leukemia treatment.
作者
梁昕悦
李登举
Liang Xinyue;Li Dengju(Department of Hematology,Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430030,China)
出处
《白血病．淋巴瘤》
CAS
2019年第4期248-251,共4页
Journal of Leukemia & Lymphoma
基金
国家自然科学基金面上项目(81770168).
关键词
自噬
急性白血病
抗药性
肿瘤
Autophagy
Acute leukemia
Drug resistance, neoplasm
