摘要
目的观察柴桂温胆定志汤联合盐酸帕罗西汀片治疗抑郁症失眠阳郁痰阻证的临床疗效。方法将北京市鼓楼中医医院和北京中医药大学国医堂门诊就诊的65例西医符合抑郁症失眠,中医符合阳郁痰阻证诊断患者,随机分为对照组32例,治疗组33例,对照组给予盐酸帕罗西汀片治疗,治疗组在盐酸帕罗西汀片治疗基础上给予柴桂温胆定志汤治疗。治疗4周后,应用汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数量表(PSQI)评估2组治疗疗效及不良反应。结果 2组均能显著降低HAMD和PSQI评分,治疗组改善抑郁状况HAMD总有效率为96.97%,高于对照组的93.73%,治疗组改善睡眠情况PSQI总有效率为96.96%,显著高于对照组的78.13%,差异有统计学意义(P<0.05)。治疗组药物不良反应发生率为5.0%,明显低于对照组17.6%(P<0.05)。结论柴桂温胆定志汤联合盐酸帕罗西汀片治疗抑郁症失眠的临床疗效确切,可提升抗抑郁效果,改善睡眠质量,并减少抗抑郁药物的不良副反应的发生,值得推广和应用。
Objective To observe the clinical efficacy of Chaigui Wendan Dingzhi decoction combined with paroxetine hydrochloride tablets in the treatment of depression with insomnia of stagnation of phlegm and blood stasis syndrome.Methods 65 western medicine practitioners from Beijing Gulou Hospital of Traditional Chinese Medicine and Guoyitang clinic of Beijing University of Chinese Medicine were in accordance with depression and insomnia.TCM patients were diagnosed with stagnation of phlegm and blood stasis syndrome.They were randomly divided into control group(n=32)and treatment group(n=33).The control group was given paroxetine hydrochloride tablets,and the treatment group was treated with Chaigui Wendan Dingzhi decoction on the basis of paroxetine hydrochloride tablets.After 4 weeks of treatment,the Hamilton Depression Scale(HAMD)and the Pittsburgh Sleep Quality Index(PSQI)were used to evaluate the efficacy and adverse effects of the two groups.Results The HAMD and PSQI scores were significantly lower in the two treatment groups.The total effective rate of HAMD in the treatment group was 96.97%,which was higher than 93.73%in the control group.The total effective rate of PSQI in the treatment group was 96.96%,which was significantly higher than 78.13%in the treatment group,and the difference was statistically significant(P<0.05).The incidence of adverse drug reactions in the treatment group was 5.0%,which was significantly lower than 17.6%in the control group(P<0.05).Conclusion Chaigui Wendan Dingzhi decoction combined with paroxetine hydrochloride tablets are effective in the treatment of depression with insomnia.It can improve antidepressant effect,improve sleep quality,and reduce the occurrence of adverse side effects of antidepressants.It is worthy of promotion and application.
作者
周培培
郝万山
ZHOU Peipei;HAO Wanshan(Department of Internal Medicine,Beijing Gulou Hospital of Traditional Chinese Medicine,Beijing 100009,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中国中医药现代远程教育》
2019年第10期81-83,共3页
Chinese Medicine Modern Distance Education of China
基金
第六批全国老中医药专家郝万山学术继承项目
北京市中医管理局薪火传承"3+3"工程
郝万山名老中医传承工作站
北京市中医药传承"双百工程"项目
北京市东城区级重点专科郁病科项目
关键词
抑郁症
失眠
柴桂温胆定志汤
depression,insomnia
Chaigui Wendan Dingzhi decoction
