摘要
目的比较卵巢癌体外药敏试验化疗方案与经验化疗方案的疗效差异。方法采用ATP-TCA法对75例卵巢癌肿瘤新鲜组织标本进行体外培养及肿瘤药物敏感性试验,选用临床常用的8种化疗药物进行测试,将化疗效果与经验化疗方案进行对比,并随访患者比较两者的差异。结果体外药敏试验结果提示75例卵巢癌标本对常见化疗药敏感性高;根据药敏结果选用中、高度敏感药物进行化疗,总有效率为77. 33%,高于对照组。药敏组无进展生存期与中位生存期分别为20. 72月及30. 30月,均长于对照组,3年生存率也高于对照组,差异有统计学意义(P <0. 05)。结论根据肿瘤药物敏感试验选用的化疗药物能有效治疗卵巢癌,对患者的个体化化疗具有一定的指导意义。
Objective To investigate the differences between in vitro chemo-sensitivity test program and empirical treatments in the treatment of patients with ovarian cancer.Methods The sensitivity of chemo-sensitivity test of 8 common used chemotherapeutic drugs on 75 ovarian cancer samples was examined by using ATP-TCA methods.The curative effects between the in vitro chemo-sensitivity test program and empirical treatment were compared and clinical outcome were followed.Results It was showed that the ovarian cancer samples had high chemo-sensitivity to the common used chemotherapeutic drugs.The medium and highly sensitive drugs were chosen for chemotherapy according to drug sensitivity results.The total effectiveness rates in the chemo-sensitivity test group were 77.33%,which was significantly higher than that in the empirical treatment group.The PFS and OS were 20.72 months and 30.30 months,respectively in the chemo-sensitivity test group,which were longer than that in the empirical treatment group.Moreover,the 3-year survival rate in the chemo-sensitivity test group was higher than that in the empirical treatment group(P<0.05).Conclusion Chemo-sensitivity testing may provide a practical method for testing new regimens before clinical trials in ovarian cancer patients.It may be helpful to determine the individualized chemotherapy.
作者
苏丹
何文静
刘屹
崔慢慢
谢兰
岳军
SU Dan;HE Wen-jing;LIU Yi;GUI Man-man;XIE Lan;YUE Jun(Department of Gynecology and Obstetrics,Sichuan Academy of Medical Sciences & Sichuan Province Hospital,Chengdu 610072,China)
出处
《实用医院临床杂志》
2019年第3期4-7,共4页
Practical Journal of Clinical Medicine
基金
四川省卫生和计划生育委员会科研基金资助项目(编号:17PJ240)
四川省科技厅科研基金资助项目(编号:2015SZ0243)
关键词
卵巢癌
体外药敏试验
个体化化疗
Ovarian cancer
Chemo-sensitivity test
Individual chemotherapy
